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Collection of Airway, Blood, and Urine Specimens for Lung Disease Research

This observational study aims to collect samples of blood, urine, and airway (breathing tube) cells from people with lung diseases like Chronic Obstructive Pulmonary Disease (COPD), Idiopathic Pulmonary Fibrosis (IPF), and Rheumatoid Arthritis-Associated Interstitial Lung Disease, as well as from healthy volunteers. The goal is to understand the causes and progression of lung diseases by comparing samples from healthy individuals to those with lung conditions. Researchers will look at genetic information and other factors in these samples. Healthy volunteers help establish what is considered "normal" so that changes seen in people with lung disease can be better understood. This study is currently looking for participants.

Study design
This is an observational study with a planned enrollment of 2000 participants. It is not a drug trial, but rather focuses on collecting biological samples.
What's involved
You would provide blood, urine, and/or airway samples. Airway samples may be collected using a bronchoscope (a thin tube inserted into the lungs).
Compensation
Not stated in the trial record.
Follow-up
Participants will receive a phone call seven days after their visit.

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NCT01776398

Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies

Recruiting
Not specifiedAges 18+Observational
Weill Medical College of Cornell University
~2,000 participants
Updated 2025-11-14 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Establishing normal ranges for various parameters
Measured over Participants upon completing the study will be followed up by a phone call seven days after their visit.

Conditions

Chronic Obstructive Pulmonary Disease (COPD)
Smoking
Smoking Cessation
Idiopathic Pulmonary Fibrosis (IPF)
Rheumatoid Arthritis-Associated Interstitial Lung Disease
Scleroderma-Associated Interstitial Lung Disease (SSC-ILD)

Explore related trials

Chronic Obstructive Pulmonary DiseaseCystic FibrosisIdiopathic Pulmonary FibrosisRheumatoid Arthritis-Associated Interstitial Lung DiseaseScleroderma-Associated Interstitial Lung DiseaseCFTR Gene

Where it's being run

1 sites across 1 states
New York1

Study leadership

  • Ronald G. Crystal, M.D. · PRINCIPAL_INVESTIGATOR · Weill Medical College of Cornell University

Who to contact

Niamh Savage
[email protected]
12127460284
Email the study team

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Eligibility criteria

Inclusion

All study subjects should be able to provide informed consent
Males or females ages 18 years and older
Must provide HIV informed consent
Must provide informed consent
Males and females age 18 years and older
Lung disease proven by at least one of the following: symptoms consistent with pulmonary disease; (2) chest X-rays consistent with lung disease; (3) pulmonary function tests consistent with lung disease; (4) lung biopsy consistent with lung disease; (5) family history of lung disease; and/or (6) diseases of organs with known association with lung disease
Must provide HIV informed consent
Must provide informed consent
Males and females, age 18 years and older
Lung disease proven by at least one of the following: (1) symptoms consistent with pulmonary disease; (2) chest X-rays consistent with lung disease; (3) pulmonary function tests consistent with lung disease; (4) lung biopsy consistent with lung disease; (5) family history of lung disease; (6) diseases of organs with known association with lung disease, and (7) individuals with the blood eosinophil levels of 5% or greater.
Must provide informed consent
Males and females, age 18 years and older
Lung disease proven by at least one of the following: symptoms consistent with pulmonary disease; (2) chest X-rays consistent with lung disease; (3) pulmonary function tests consistent with lung disease; (4) lung biopsy consistent with lung disease; (5) family history of lung disease; and (6) diseases of organs with known association with lung disease

Exclusion

Individuals not deemed in good overall health by the investigator during screening visits and/or prior to the bronchoscopy will not be accepted into the study.
Individuals with history of chronic lung disease, including asthma or with recurrent or recent (within three months) acute pulmonary disease will not be accepted into the study.
Individuals with allergies to atropine or any local anesthetic will not be accepted into the study.
Individuals with allergies to pilocarpine, isoproterenol, terbutaline, atropine or aminophylline will not be accepted into the study.
Females who are pregnant or nursing will not be accepted into the study
Any history of allergies to xylocaine, lidocaine, versed, valium, atropine, pilocarpine, isoproterenol, terbutaline, aminophylline, or any local anesthetic will not be included in the study
Individuals deemed unable to complete the bronchoscopy due to health concerns by the investigator.
Females who are pregnant or nursing
Experienced a recent (≤ 8 weeks) pulmonary exacerbation of their disease
Patient refuses consent
Patient refuses consent

What this trial measures

  • Establishing normal ranges for various parametersParticipants upon completing the study will be followed up by a phone call seven days after their visit.

    The primary objective of the study is to obtain biologic materials from the blood, airways and/or urine of normal individuals and individuals with lung disease. The normal are used to establish a set of normal ranges for various parameters. These provide control information when compared to individuals with various pulmonary diseases, and will help in understanding the etiology and pathogenesis of various lung diseases.