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Understanding Glucose Metabolism After Gastric Bypass Surgery

This study aims to understand how gastric bypass surgery improves the body's ability to handle sugar (glucose metabolism). Researchers believe that changes in the gut after surgery lead to more "incretin" hormones, which help the body make more insulin. You might be able to join if you are 18-65 years old, had gastric bypass surgery, and either have healthy blood sugar or experience low blood sugar (recurrent hypoglycemia) after surgery. Participants will receive exendin-(9-39) during tests to measure insulin and other hormone levels after meals. The study will track these levels for up to one year to see how much GLP-1 (a type of incretin) contributes to insulin production. The current recruitment status is unclear.

Study design
This is an interventional study with a planned enrollment of 80 participants. The phase of the study is not specified.
What's involved
You would participate in up to 10 sessions over a year, involving meal tolerance tests with exendin-(9-39) infusions and measurements of glucose and hormone levels.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 1 year.

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NCT01803451

Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass

Recruiting
EARLY_PHASE1Ages 18–65Interventional
The University of Texas Health Science Center at San Antonio
~80 participants
Updated 2025-09-09 on ClinicalTrials.gov
What's tested:exendin-(9-39)exendin -(9-39)

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
The investigator measure glucose, islet and GI hormonal levels in response to meal ingestion as a composite measure and the percentage of contribution of GLP-1 contribution to postprandial insulin levels will also be calculated
Measured over up to 1 year (10 sessions)

Conditions

Post-bariatric Surgery

Explore related trials

Bypass of stomachHypoglycemia

Where it's being run

2 sites across 1 states
Texas2

Study leadership

  • Marzieh Salehi, MD,MS · PRINCIPAL_INVESTIGATOR · Marzieh Salehi

Who to contact

Marzieh Salehi, MD MS
[email protected]
210-567-6691
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

age 18-65
healthy control without diabetes or active organ disease
Individuals with bariatric surgery
recurrent hypoglycemia post gastric bypass

Exclusion

pregnancy
significant anemia
diabetes currently unless pre-op for bariatric surgery procedure
GI obstruction

What this trial measures

  • The investigator measure glucose, islet and GI hormonal levels in response to meal ingestion as a composite measure and the percentage of contribution of GLP-1 contribution to postprandial insulin levels will also be calculatedup to 1 year (10 sessions)