This observational study is looking into why some people with cystic fibrosis (CF) develop cystic fibrosis related diabetes (CFRD). CFRD can lead to worse health outcomes for people with CF. Researchers believe that some of the same genetic factors involved in type 2 diabetes (T2DM) might also play a role in CFRD. This study will collect a blood or saliva sample from participants to look at specific genes, including TCF7L2 and about ten others linked to T2DM. They will then compare how insulin and incretins (hormones that help control blood sugar) work in people with different genetic profiles. The goal is to better understand the mechanisms behind CFRD development. You may be able to join if you are at least 2 years old, have a diagnosis of Cystic Fibrosis, and do not have a diagnosis of non-CFRD diabetes like Type 1 Diabetes.

Study design

This is an observational study planning to enroll 550 participants. It will examine genetic factors and their link to insulin and incretin secretion in people with cystic fibrosis.

What's involved

You would provide a single blood or saliva sample for genetic testing. Your medical records would also be reviewed.

Compensation

Not stated in the trial record.

Follow-up

Blood samples for DNA genotyping are measured at 1 day, which is the primary endpoint.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.