High Resolution Retinal Imaging for Eye Conditions

This observational study uses special imaging techniques, including adaptive optics imaging, optical coherence tomography, and fundus photography, to take very detailed pictures of the retina (the light-sensitive tissue at the back of your eye). The goal is to better understand how the retina looks and works in people with and without eye conditions like Stargardt disease, Retinitis Pigmentosa, Age-related Macular Degeneration, Choroideremia, and Geographic Atrophy. You may be able to join if you are 7 years or older. The study aims to get high-resolution images of your retina, specifically focusing on the cone photoreceptor mosaic (cells that detect light and color), blood vessels, and other retinal layers. The current recruitment status is unclear.

Study design
This is an observational study with a planned enrollment of 600 participants. It involves case-control studies where participants with eye conditions will be followed over time.
What's involved
You would have retinal imaging procedures, including adaptive optics imaging, optical coherence tomography, and fundus photography, during an initial visit that lasts one day.
Compensation
Not stated in the trial record.
Follow-up
Cases will be followed over time, but specific follow-up duration is not provided.

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NCT01866371

High Resolution Retinal Imaging

Recruiting
Not specifiedAges 7+Observational
University of Pennsylvania
~600 participants
Updated 2026-05-05 on ClinicalTrials.gov
What's tested:Retinal imaging

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
high-resolution images of retina
Measured over 1 day (initial visit)
Stargardts
Retinitis Pigmentosa
Age-related Macular Degeneration
Choroideremia
Geographic Atrophy
1 sites across 1 states
Pennsylvania1
  • Jessica IW Morgan, PhD · PRINCIPAL_INVESTIGATOR · University of Pennsylvania

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Eligibility criteria

Inclusion

Males or females age 7 years or older.
Parental/guardian permission (informed consent) and if appropriate, child assent. Child subjects age 7-17 must give assent.
Reasonable compliance with an imaging protocol as determined by the study personnel.

Exclusion

Individuals that are at risk to acute glaucoma.
Individuals that are photophobic and experience adverse psychological reactions to flashes of light.
Ocular opacities, high refractive error, and high frequency of nystagmus as determined by the study team.
  • high-resolution images of retina1 day (initial visit)

    The primary objective of this study is to obtain and analyze high-resolution images of the retina in normal and diseased eyes non-invasively.