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Ovarian Tissue Transplantation for Infertility

This study is testing a procedure called ovarian tissue transplantation. This involves taking ovarian tissue that was previously frozen and transplanting it back into women who are infertile or have ovarian insufficiency (when ovaries don't work properly) after cancer treatments. The goal is to see if this procedure is safe and effective in helping women become pregnant and get their menstrual periods back. You might be able to join if you are a woman between 18 and 45 years old, have previously frozen ovarian tissue, have ovarian insufficiency (FSH over 10), and haven't been able to get pregnant after six months of unprotected intercourse. The study is currently unclear on its recruitment status and plans to enroll 10 participants.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 10 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for pregnancy and return of menstrual function for 5 years.

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NCT01870752

Ovarian Tissue Transplantation

Recruiting
NAAges 18–45InterventionalTreatment
Abramson Cancer Center at Penn Medicine
~10 participants
Updated 2025-09-10 on ClinicalTrials.gov
What's tested:Transplantation of previously cryopreserved ovarian tissu

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pregnancy
Measured over 5 years
+1 more outcome measured

Conditions

Infertile Females or Females With Ovarian Insufficiency

Explore related trials

InfertilityOvarian Failure

Where it's being run

1 sites across 1 states
Pennsylvania1

Study leadership

  • Clarisa R Gracia, MD · PRINCIPAL_INVESTIGATOR · Abramson Cancer Center at Penn Medicine

Who to contact

Clarisa Gracia, MD
[email protected]
877-204-9213
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Female patient between the ages of 18 and 45 years
Previously cryopreserved and stored cortical ovarian tissue available for autologous transplantation
Ovarian insufficiency defined as an elevated FSH over 10
Inability to conceive after 6 months of unprotected intercourse with male
Reasonably good health
Candidate for pregnancy
Written clearance for the procedure from the patients oncologist

Exclusion

Patients considered to be high risk for surgical complications will be excluded from the research protocol
Women who are known to be positive for the BRCA mutation
Women with a history of leukemia, ovarian cancer or a cancer that likely involved the ovaries at the time of ovarian tissue collection
Women with psychological, psychiatric, or other conditions which prevent giving fully informed consent
Current pregnancy

What this trial measures

  • Pregnancy5 years
  • Return of menstrual function5 years