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Understanding Thinking and Memory Problems in People With HIV

This observational study is looking at how thinking and memory problems (known as HAND) develop in people with HIV. Researchers want to understand why some people with HIV, even those with low levels of the virus in their blood, still experience these issues. The study aims to follow about 500 people with HIV and 250 healthy volunteers for up to ten years to see how HIV might affect the brain. There are no specific interventions or drugs being tested. The main goal is to learn more about the natural course of HAND in people who have successfully suppressed the HIV virus in their blood. You can join if you are between 18 and 110 years old.

Study design
This is an observational study involving approximately 1150 participants, including people with HIV and healthy volunteers. It is not testing any specific treatments.
What's involved
You would undergo a screening and evaluation, including blood and urine tests, memory and thinking tests, and a brain MRI. You may also have the option of a lumbar puncture (spinal tap) and an eye exam. These assessments will be repeated yearly for up to ten years.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed annually for up to ten years.

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NCT01875588

Thinking and Memory Problems in People With HIV

Recruiting
Not specifiedAges 18+Observational
National Institute of Neurological Disorders and Stroke (NINDS)
~1,150 participants
Updated 2026-08-07 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
To characterize in detail the natural course of HAND in subjects with prolonged plasma HIV virologic suppression (<50 copies/mL).
Measured over Annually

Conditions

HIV Positive

Explore related trials

HealthyHIV Infection

Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • Avindra Nath, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Neurological Disorders and Stroke (NINDS)

Who to contact

Amanda M Wiebold
[email protected]
(301) 538-9531
Email the study team

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What this trial measures

  • To characterize in detail the natural course of HAND in subjects with prolonged plasma HIV virologic suppression (<50 copies/mL).Annually

    The prevalence of neurocognitive impairment in this cohort will be high despite HIV plasma viremia below the limit of detection (BLD) in the blood as chronic activation may be mediating neuronal damage and result in cognitive impairment.