Quantitative MRI for Myelofibrosis

This study is looking at whether a special type of MRI (magnetic resonance imaging) scan, called T1 Weighted MRI, can help doctors understand how well treatments for myelofibrosis are working. Myelofibrosis is a condition where the bone marrow, which makes blood cells, is scarred. Researchers want to see if changes in these MRI scans can show how much the disease has spread and if treatment is effective. You might be able to join if you are an adult (18-99 years old) with a diagnosis of myelofibrosis and can have an MRI scan without any issues. The goal is to see if these MRI changes can predict treatment response earlier than current methods, with results expected in 5 years. The current status of this study is unclear.

Study design
This is an observational study, meaning researchers will watch and collect information from 192 participants. It is not specified if this study has different phases.
What's involved
You would have an MRI scan at the beginning of the study, again around 6 months (at the time of a scheduled bone marrow biopsy or end of treatment cycle), and a final scan after 12 months.
Compensation
Not stated in the trial record.
Follow-up
The primary goal of this study is to assess treatment response using MRI over 5 years.

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NCT01973881

Quantitative MRI for Myelofibrosis

Recruiting
Not specifiedAges 18–99Observational
University of Michigan Rogel Cancer Center
~192 participants
Updated 2026-07-31 on ClinicalTrials.gov
What's tested:T1 Weighted MRI (magnetic resonance imaging)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Using MRI to assess treatment response in subjects with myelofibrosis
Measured over 5 years
Myelofibrosis
1 sites across 1 states
Michigan1
  • Gary Luker, M.D. · PRINCIPAL_INVESTIGATOR · University of Michigan Hospital

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  • Using MRI to assess treatment response in subjects with myelofibrosis5 years

    For the development and validation of functional magnetic resonance imaging parameters as biomarkers for analyzing extent of disease and quantifying response to treatment in patients with myelofibrosis. Quantitative MRI parameters for diffusion of water and/or fat content in bone marrow will determine extent of disease in patients with myelofibrosis, and changes in these parameters will predict response to therapy. To investigate this hypothesis, the researchers will perform this pilot clinical study of diffusion and fat content (T1 weighted imaging) in patients before and during treatment for myelofibrosis. The researchers expect to identify MRI parameters that determine the extent and severity of bone marrow disease in these patients and determine response to therapy at earlier time points than currently used clinical parameters.