Study on Genetic Causes of Severe Early Childhood Obesity

This study is looking for children and adults with severe obesity that started before they were 6 years old. The goal is to find new or known genetic changes that might cause this type of obesity. Researchers will ask you about your health and eating habits, do a quick physical exam, and collect a saliva or blood sample for genetic testing. Family members are also invited to join. This study is observational, meaning it involves watching and collecting information, not giving any new treatments. The main goal is to identify genetic causes of obesity, with results expected in about 1.5 to 2 years.

Study design
This is an observational study aiming to enroll 500 participants. It is designed to investigate genetic causes of severe early childhood obesity.
What's involved
You would answer questions about your health and eating behavior, have a brief physical examination, and provide a saliva or blood sample for genetic testing.
Compensation
Not stated in the trial record.
Follow-up
The primary goal of identifying genetic variants is measured at 1.5 to 2 years.

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NCT01998750

Study to Investigate Genetic Causes of Severe Early Childhood Onset Obesity.

Recruiting
Not specifiedUp to 80Observational
Columbia University
~500 participants
Updated 2025-10-21 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Identification of known or novel genetic variants in genes that underlie obesity.
Measured over 1.5-2 years
Obesity
2 sites across 2 states
Massachusetts1
New York1
  • Vidhu Thaker, M.D. · PRINCIPAL_INVESTIGATOR · Columbia University

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Do you actually qualify for this trial?

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Eligibility criteria

Exclusion

Known genetic causes of obesity
Known Endocrine causes of obesity.
Neurologic tumor, trauma or surgery
Prior malignancy or transplant
Known autoimmune diseases
Edema of a known or unknown cause
Prolonged steroid use.
  • Identification of known or novel genetic variants in genes that underlie obesity.1.5-2 years

    Identification of known or novel genetic variants in genes that underlie obesity.