This study looks at what happens after an islet transplant (a procedure to replace insulin-producing cells) for Type 1 Diabetes doesn't work. Specifically, it's observing how your body reacts when you stop taking medicines like sirolimus, tacrolimus, MMF, and Myfortic® that prevent your body from rejecting the transplant. The main goal is to see how often your body develops "allosensitization" (a reaction where your immune system becomes sensitive to foreign tissues) after your transplant has failed, and how long this sensitivity lasts. You can join if you are 18 to 75 years old, have Type 1 Diabetes, and have had at least one islet transplant without any other organ transplants. The study aims to understand the rate of allosensitization at 3 years after transplant failure and monitor it for 10 years.

Study design

This is an observational study, meaning researchers will watch what happens without giving new treatments. It plans to include 60 participants.

What's involved

After your islet transplant has failed, you will stop taking your immunosuppression medications and be monitored for 10 years. Your blood will be checked for allosensitization using panel reactive antibody (PRA) levels at 3, 6, and 9 years.

Compensation

Not stated in the trial record.

Follow-up

Participants will be monitored for 10 years after stopping immunosuppression.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.