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Observational Study on Factors for Weight Loss and Maintenance

This observational study, conducted by the University of Michigan's Weight Management Program, aims to understand what individual factors (phenotypic factors) help people successfully lose weight and keep it off long-term. The researchers believe that a "one-size-fits-all" approach doesn't work for obesity. They will study 3200 participants, including those who are obese (BMI of 27 kg/m2 or higher) and those who are lean (BMI between 17 and 27 kg/m2), aged 15 to 75 years. The study will look at changes in these factors over 3-6 months and again at 2 years. This study is currently active but its recruitment status is unclear.

Study design
This is an observational study involving 3200 participants. It is not a randomized or blinded study.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Researchers will follow up with participants to measure changes in phenotypic factors at 3-6 months and again at 2 years.

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NCT02043457

Identification of Phenotypic Factors That Predict Success for Weight Loss and Long-term Weight Maintenance

Recruiting
Not specifiedAges 15–75Observational
University of Michigan
~3,200 participants
Updated 2026-07-13 on ClinicalTrials.gov
What's tested:phenotyping

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Phenotypic factors related to weight loss and long-term weight maintenance
Measured over Change in phenotypic factors from baseline to 3-6 months and at 2 years

Conditions

Obesity

Explore related trials

Obesity

Where it's being run

1 sites across 1 states
Michigan1

Study leadership

  • Charles Burant, MD, PhD · STUDY_DIRECTOR · University of Michigan

Who to contact

Amy E Rothberg, MD, PhD
[email protected]
734-647-5871
Email the study team

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Eligibility criteria

Inclusion

Obese males and females: age \>20 years; Obese population defined as BMI \> or = 27 kg/m2
Lean population BMI \< 27 but \> 17 kg/m2
Able and willing to provide written informed consent for the trial

Exclusion

Evidence of inherited disorders of lipid metabolism.
History of Cancer within the last 5 years
Human immunodeficiency virus (HIV) antibody positive.
Patients with solid organ transplants.
Participation in any other clinical trial within 90 days of entry into this trial.
Pregnant or lactating females.
Uncontrolled thyroid disease
Unstable angina or NY heart association class II failure or above
Gastrointestinal disease specifically GI motility disorders
Unstable neuropsychiatric disease including major depression/anxiety, eating disorder such as binge eating, bulimia or anorexia
End stage renal or hepatic disease
Autoimmune disorders (e.g. SLE)
Body weight fluctuation of more than 5 kg in the previous 3 months
Prior bariatric surgery
A history or current alcohol/substance abuse and change in smoking habits or cessation in the past 6 months.
Women of childbearing age must use a reliable form of contraception.
Any medical condition, which in the opinion of the investigator would make the patient unsuitable for recruitment, or could interfere with the patient participating in or completing the protocol.
Unwilling or unable to consent for the study.

What this trial measures

  • Phenotypic factors related to weight loss and long-term weight maintenanceChange in phenotypic factors from baseline to 3-6 months and at 2 years

    Phenotypic factors include: blood glucose levels, lipomic/metabolomic measurements, genetic analysis, body fat percentage, maximal oxygen consumption, respiratory quotient, resting metabolic rate, physical/emotional health