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Comparing Microfracture and Stem Cells for Knee Cartilage Repair

This study is comparing two ways to treat knee cartilage damage: microfracture and adipose-derived stem cells (ADSCs). Microfracture is a standard surgery that encourages your body to grow new cartilage. The ADSC method uses stem cells taken from your own fat to help repair the cartilage. Researchers want to see if ADSCs can lead to better cartilage repair than microfracture. You might be able to join if you are between 18 and 50 years old and have a specific type of cartilage defect in your knee. The main goal is to see how your knee health scores change over 24 months after the procedure. The current status of this study is unclear, and it plans to enroll 17 participants.

Study design
This interventional study plans to enroll 17 participants to compare two surgical methods for knee cartilage repair. It is not specified if the study is randomized or blinded.
What's involved
You would undergo arthroscopy to prepare the cartilage defect. If in the ADSC group, you would also have fat removed from your knee for stem cell processing and then have the stem cells applied to the defect.
Compensation
Not stated in the trial record.
Follow-up
Your knee health will be checked at baseline, 6 months, 12 months, and 24 months after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT02090140

Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage Defects

UNKNOWN
NAAges 18–50InterventionalTreatment
University of Colorado, Denver
~17 participants
Updated 2024-04-25 on ClinicalTrials.gov
What's tested:ADSC ApplicationMicrofracture

At a glance

Recruiting sites
2 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Health Scores on the KOOS Questionnaire
Measured over Completed at baseline, 6 months, 12 months, and 24 months post-operatively.

Conditions

Degenerative Lesion of Articular Cartilage of Knee

Explore related trials

Defect of articular cartilage

NCT02090140

Where you'd take part

This study runs at 3 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Kerlan Jobe Orthopedic Institute

    Santa Monica, Californiastudy coordinator listed

    Recruiting

  • UC Health Steadman Hawkins Clinic - Denver Inverness

    Denver, Coloradostudy coordinator listed

    Recruiting

  • Stanford Medical Outpatient Center

    Redwood City, Californiano site contact published

    Active, not recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Jason Dragoo, MD · PRINCIPAL_INVESTIGATOR · University of Colorado, Denver
  • Seth L Sherman, MD · PRINCIPAL_INVESTIGATOR · Stanford University

Who to contact

Kaitlyn Whitney
[email protected]
(720) 872-4836
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Must be between ages 18 and 50 years.
Must have a discrete, contained chondral defect less than 400mm\^2 located on the medial or lateral femoral condyle
Must have overall neutral lower limb mechanical alignment (\<5 degrees varus or valgus).

Exclusion

Ages younger than 18 years and older than 50 years.
If they have undergone previous chondral procedures
If they have pre-existing osteoarthritis (Kellegren-Lawrence Grade ≥2)
If they have a BMI \>30.

What this trial measures

  • Health Scores on the KOOS QuestionnaireCompleted at baseline, 6 months, 12 months, and 24 months post-operatively.

    The Knee Osteoarthritis Outcome Score (KOOS), a standard outcome questionnaire for the assessment of health-related quality of life, will be completed.