Germ Cell Tumor and Testicular Tumor DNA Registry

This study is creating a registry to better understand germ cell tumors (GCT) and other testicular tumors. Researchers will collect questionnaires and a sample of your blood or saliva for DNA analysis. This registry will help us learn more about how to prevent, diagnose, treat, and understand the outcomes of these tumors. We are looking for people aged 18 or older who have been diagnosed with or are suspected of having a germ cell tumor or testicular mass, as well as their English-speaking blood relatives. We also welcome English-speaking individuals who do not have these tumors and are not related to someone who does. The goal is to create this registry over five years, which will help us understand why some people develop these tumors and others do not. The current recruitment status is unclear.

Study design: This is an observational study aiming to enroll 1000 participants. It is designed to create a registry of individuals with germ cell tumors, testicular tumors, and their family members.
What's involved: You will be asked to complete questionnaires and provide a sample of blood (2-4 tubes) or saliva (one tablespoon) for DNA extraction. If you have already provided a DNA sample for another MSKCC study, you may not need to provide another one.
Compensation: Not stated in the trial record.
Follow-up: The primary goal is the creation of the registry, measured at 5 years. It is not specified how long individual participants will be followed after providing samples.

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Germ Cell Tumor and Testicular Tumor DNA Registry

Recruiting

Not specifiedAges 18+Observational

Memorial Sloan Kettering Cancer Center

~1,000 participants

Updated 2026-02-04 on ClinicalTrials.gov

What's tested:Questionnairessample of blood or saliva

At a glance

Recruiting sites

6 of 8 listed sites are recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

creation of a Germ Cell Tumor and testicular tumor registry

Measured over 5 years

Conditions

Germ Cell Tumor

Testicular Tumor

Where it's being run

8 sites across 2 states

New York5

New Jersey3

Study leadership

Darren Feldman, MD · PRINCIPAL_INVESTIGATOR · Memorial Sloan Kettering Cancer Center

Who to contact

Darren Feldman, MD

646-422-4491

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Must be ≥ 18 years of age AND

Must be an English-speaker AND

Must have a diagnosis or suspicion of germ cell tumor and/or a testicular mass

Must be ≥ 18 years of age AND

Must be an English-speaker AND

Must be a blood relative of the proband. Family members of probands are eligible. These individuals need not have a diagnosis of GCT-TT, as they will be used for segregation analysis of suspected variants found in the proband.

Must be ≥ 18 years of age AND

Must be an English-speaker AND

Must not have a personal history of cancer, with the exception of non-melanoma skin cancer, AND

Must not have a family history of germ cell tumor or testicular tumor AND

Must not be a blood relative of controls enrolled in this study

What this trial measures

creation of a Germ Cell Tumor and testicular tumor registry5 years
We will collect clinical data including diagnosis date, pathology, family history, and risk factors in patients with GCT-TT.

Trialytics