Brillouin Microscopy for Corneal Ectasia

This study is testing a new way to look at the eye called Brillouin imaging. Researchers want to see if Brillouin imaging can help diagnose conditions like keratoconus (a thinning of the cornea, the clear front part of your eye) and ectasia (a bulging of the cornea). They will compare the stiffness of the cornea in healthy people, those with keratoconus, and those who have had LASIK eye surgery. The main goal is to measure the cornea's stiffness to see if this imaging technique can be a useful diagnostic tool. The study is currently unclear on its recruitment status. You may be able to join if you are between 20 and 75 years old and have healthy corneas, keratoconus, or have had LASIK surgery without problems in the last year.

Study design
This is an observational study, meaning researchers will observe participants without providing a specific treatment. It plans to enroll 168 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The Elastic Modulus of the Cornea was measured between 2012 and 2022.

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NCT02118922

A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia

Recruiting
Not specifiedAges 20–75Observational
Massachusetts General Hospital
~168 participants
Updated 2025-11-06 on ClinicalTrials.gov
What's tested:Brillouin imaging

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Elastic Modulus of the Cornea
Measured over 2012-2022
Keratoconus
Ectasia
Crosslinking
Fuchs' Endothelial Dystrophy
1 sites across 1 states
Massachusetts1
  • Andy Yun, PhD · PRINCIPAL_INVESTIGATOR · Masachusetts General Hospital

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Do you actually qualify for this trial?

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Eligibility criteria

Exclusion

Have occludable narrow angles (without a patent peripheral iridotomy)
Monocular subjects
Do not or cannot understand the instructions for the imaging
  • Elastic Modulus of the Cornea2012-2022

    Patients will be measured one time only at their imaging session