Ketamine for Depression and Alcoholism
This study is looking at how ketamine, a drug, affects people with major depression that hasn't responded well to other treatments (treatment-resistant depression). Researchers are particularly interested in whether a family history of alcohol problems changes how well ketamine works. They want to see if ketamine can help improve depression symptoms. You might be able to join if you are between 18 and 55 years old and have major depression. The main way they will measure success is by checking your depression symptoms using a scale called the Montgomery-Åsberg Depression Rating Scale (MADRS) from before the ketamine treatment to one week after. The current status of this study is unclear, and it plans to enroll 60 participants.
- Study design
- This is an interventional study, meaning participants will receive a specific treatment. It aims to enroll 60 participants.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your depression symptoms will be measured from before the ketamine infusion to one week after.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Ketamine Alcohol (in Treatment-Resistant Depression)
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Mark J Niciu, M.D. Ph.D. · PRINCIPAL_INVESTIGATOR · University of Iowa Health Care (UIHC)
Who to contact
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What this trial measures
- Montgomery-Åsberg Depression Rating Scale (MADRS)Pre-ketamine (baseline) to one week post-ketamine infusion
The MADRS contains 10 items, and each item is scored 0-6. These item scores are summed to create a scale score; thus, scale scores range from 0 to 60. A scale score of 0 indicates the absence of depressive symptoms, while a score of 60 indicates severe depression. The primary outcome is the mean change in total MADRS score. A decrease in the mean MADRS score indicates a decrease (or improvement) in depressive symptoms, whereas an increase in the mean MADRS score indicates an increase (or worsening) in depressive symptoms.