Understanding Lung and Thymic Cancers Through Tissue Samples

This study aims to better understand lung and thymic cancers by collecting tissue samples. Researchers hope this will lead to new ways to diagnose and treat these diseases. You may be able to join if you are an adult (18 or older) with non-small cell lung cancer, small cell lung cancer, extrapulmonary small cell cancer, pulmonary neuroendocrine tumors, or thymic epithelial tumors. The study is observational, meaning it focuses on collecting information and samples rather than testing a specific treatment. The main goal is to acquire samples for ongoing research into these cancers. The current recruitment status is unclear.

Study design
This is an observational study with a planned enrollment of 2000 participants. It is designed to collect information and samples from people with specific types of lung and thymic cancers.
What's involved
You will have a medical history taken, a physical exam, and blood tests. You may also be asked to provide urine and blood samples and answer questions about your daily activities.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

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NCT02146170

Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors

Recruiting
Not specifiedAges 18+Observational
National Cancer Institute (NCI)
~2,000 participants
Updated 2026-08-28 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Allow sample acquisition for use in the study of thoracic malignancies except mesothelioma.
Measured over Ongoing
Non-Small Cell Lung Cancer
Small Cell Lung Cancer
Extrapulmonary Small Cell Cancer
Pulmonary Neuroendocrine Tumors
Thymic Epithelial Tumors
1 sites across 1 states
Maryland1
  • Arun Rajan, M.D. · PRINCIPAL_INVESTIGATOR · National Cancer Institute (NCI)

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Eligibility criteria

Inclusion

Individuals with histologically or cytologically confirmed NSCLC, SCLC, ESCC, PNET, and TET.
Individuals consulted in the Clinical Center without a definitive diagnosis, but clinically considered likely to have a malignancy of the above histologies, pending further tissue acquisition and/or pathology review.
Age greater than or equal to18 years. Children are excluded from the study, as the above thoracic malignancies are rare in this population.
Ability of subject to understand and the willingness to sign a written informed consent document.

Exclusion

Active symptomatic major organ disorder that would increase the risk of biopsy, including but not limited to ischemic heart disease, recent myocardial infarction, active congestive heart failure, pulmonary dysfunction.
Active concomitant medical or psychological illnesses that may increase the risk to the subject, at the discretion of the Principal Investigator.
Known HIV-positive individuals not on combination antiretroviral therapy are ineligible.
  • Allow sample acquisition for use in the study of thoracic malignancies except mesothelioma.Ongoing

    blood, tumor, body fluids, and normal tissue samples