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Observational Study on H. Pylori and Gastric Cancer

This research study is for people who currently have or previously had an H. pylori infection, or have gastric (stomach) or esophageal (food pipe) cancer, and are planning to have a routine endoscopy. The study aims to understand how H. pylori infections can lead to gastric cancer and if early interventions are possible. Researchers will collect an additional biopsy (a small tissue sample) during your routine endoscopy. These samples will be used to identify genetic changes linked to H. pylori infection and examine the specific H. pylori strains and other stomach bacteria present. The goal is to better understand the connection between H. pylori and gastric cancer development.

Study design
This is an observational study involving 110 participants. It is not testing a new drug or treatment.
What's involved
You would undergo a routine upper endoscopy, during which up to four additional tissue biopsies will be collected from areas already being sampled.
Compensation
Not stated in the trial record.
Follow-up
Genomic alterations associated with H. pylori infection will be measured within 3 years of tissue collection.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT02164409

Changes Associated With H. Pylori and Gastric Carcinogenesis

Active, Not Recruiting
Not specifiedAges 18+Observational
Weill Medical College of Cornell University
~110 participants
Updated 2026-06-01 on ClinicalTrials.gov
What's tested:Endoscopy tissue collection

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Identify genomic alterations associated with H. pylori infection
Measured over Within 3 years of tissue collection

Conditions

Bacterial Infection Due to Helicobacter Pylori (H. Pylori)

Explore related trials

Barrett EsophagusEsophageal CarcinomaGastric CarcinomaHelicobacter Pylori Infection

Where it's being run

1 sites across 1 states
New York1

Study leadership

  • Manish Shah, MD · PRINCIPAL_INVESTIGATOR · Weill Medical College of Cornell University

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patient must be 18 years or older
Patient must have active or prior H. pylori infection, or have been treated for H.pylori infection in the past, as assessed by ELISA (not applicable for the subset of patient controls) or have gastric or esophageal cancer or have Barrett's Esophagus
Patients must be eligible for and are planning to undergo a routine upper endoscopy and tissue biopsy
Patients must sign informed consent

Exclusion

Prior history of upper GI bleed (within 3 months)
Bleeding disorder or coagulopathy
Recent stroke or myocardial infarction (within 3 months)

What this trial measures

  • Identify genomic alterations associated with H. pylori infectionWithin 3 years of tissue collection

    Ability to obtain adequate tissue for next generation sequencing from endoscopy