Back to search results

Influenza Immunization in Adults Over Age 75

This study is looking at how the immune systems of people over 75 respond to the flu shot (Influenza BIOLOGICAL). Researchers want to understand if a common virus called cytomegalovirus (CMV) affects this response. You might be able to join if you are over 75 and don't have allergies to eggs or vaccines, active cancer, or certain inflammatory conditions. The study aims to see if CMV viral DNA is present in your blood cells at the end of each flu season for four years. This will help them understand what makes the flu shot more or less effective in older adults. About 1025 people will participate.

Study design
This is an interventional study planning to enroll 1025 participants. The phase of the study is not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for the presence of CMV Viral DNA in Peripheral Blood Monocytes at the end of each flu season for the next 4 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT02200276

Influenza Immunization in Adults Over Age 75

Recruiting
NAAges 75+InterventionalPrevention
Johns Hopkins University
~1,025 participants
Updated 2026-03-16 on ClinicalTrials.gov
What's tested:Influenza

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Presence of CMV Viral DNA in Peripheral Blood Monocytes
Measured over At the end of each flu season for the next 4 years

Conditions

Influenza
Immunization
Older Adults
Over Age 75

Explore related trials

Influenza

Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • Sean Leng · PRINCIPAL_INVESTIGATOR · Johns Hopkins University

Who to contact

Trudymae Agboka, M.S. Biology
[email protected]
410-550-5744
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Adults over age 75 years

Exclusion

Allergies to egg or vaccine
Active malignancies
On radiation or chemotherapy
Active systemic inflammatory diseases including rheumatoid arthritis, Crohn's disease, and ulcerative colitis
Acute exacerbation of chronic cardiopulmonary conditions including decompensated CHF or COPD
Taking oral steroids (such as prednisone) or immune modulating drugs (such as methotrexate).
Lacking the capacity to consent (individuals who do not understand what Flu shot is or need someone else to decide if s/he should get the Flu shot)

What this trial measures

  • Presence of CMV Viral DNA in Peripheral Blood MonocytesAt the end of each flu season for the next 4 years

    To assess the role of chronic CMV infection as defined by presence of CMV viral DNA in peripheral monocytes as a risk factor for vaccine failure in this oldest old subset.