NIAAA Natural History Protocol for Alcohol Use

This observational study aims to better understand alcohol problems by gathering information from people with and without alcohol use disorder (AUD). Researchers will collect a wide range of information, including clinical details, behaviors, and genetic data, from adults aged 18 to 100. This includes individuals seeking treatment for AUD, those who are not seeking treatment, and healthy volunteers. The goal is to create a comprehensive dataset that will help scientists explore the impact of alcohol use on overall health and identify potential candidates for future research studies. This study does not involve any specific interventions or treatments.

Study design
This is an observational study with a planned enrollment of 7500 participants. It is designed to collect a broad range of information across the alcohol use spectrum.
What's involved
Participants will complete the study, including genetic and MRI tests. A standard set of data will be collected.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint involves obtaining phenotypic assessments measured at a single point in time (cross-sectional).

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NCT02231840

NIAAA Natural History Protocol

Recruiting
Not specifiedAges 18+Observational
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
~7,500 participants
Updated 2026-08-31 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Obtain phenotypic assessments
Measured over CROSS SECTIONAL
Alcohol Use Disorder
1 sites across 1 states
Maryland1
  • Nancy Diazgranados, M.D. · PRINCIPAL_INVESTIGATOR · National Institute on Alcohol Abuse and Alcoholism (NIAAA)

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Eligibility criteria

Inclusion

Age \>=18 years of age
Willingness to complete the study including genetic and MRI tests.
Treatment-seeking individuals (Patients that want to stop alcohol use and will require medical management to achieve sobriety) and
Non-treatment-seeking participants (Patients or healthy volunteers who want to continue their current alcohol use).

Exclusion

Individuals \< 18 years of age
Prisoners
Pregnant candidates
Candidates having a severe medical or mental health disorder that would impair participation in the study
  • Obtain phenotypic assessmentsCROSS SECTIONAL

    To gather characterization measures for individuals wishing to participate in this protocol, including a standardized set of clinical, behavioral, biochemical, and structural MRI-based phenotypic assessments, as well as whole genome genotypes