PPHNet Informatics Registry for Pediatric Pulmonary Hypertension

This study is an observational registry, meaning researchers are collecting information about children with pulmonary hypertension (high blood pressure in the lungs) to better understand the disease. They believe childhood pulmonary hypertension is different from adult forms and hope to learn more about its causes, how it progresses, and what treatments work best. You may be able to join if you are between 1 day and 21 years old, and your pulmonary hypertension started before you were 18. The main goal is to track how long it takes for a patient's condition to worsen, measured over 12 months. This study is currently unclear on its recruitment status and is not testing any specific interventions or drugs.

Study design
This is an observational study aiming to enroll 2500 participants. It is not testing a specific treatment, but rather collecting information.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, time to clinical worsening, is measured at 12 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT02249923

Pediatric Pulmonary Hypertension Network (PPHNet) Informatics Registry

Recruiting
Not specifiedAges 1–21Observational
New York Medical College
~2,500 participants
Updated 2025-03-13 on ClinicalTrials.gov

At a glance

Recruiting sites
12 of 14 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Time to clinical worsening
Measured over 12 months
Pulmonary Vascular Disease
Pulmonary Arterial Hypertension
14 sites across 12 states
California2
New York2
Colorado1
Florida1
Maryland1
Massachusetts1
Ohio1
Pennsylvania1
  • Steven H Abman, MD · PRINCIPAL_INVESTIGATOR · Children's Hospital Colorado
  • David D Ivy, MD · PRINCIPAL_INVESTIGATOR · Children's Hospital Colorado
  • Kenneth D Mandl, MD · PRINCIPAL_INVESTIGATOR · Boston Children's Hospital, Harvard School of Medicine
  • Roberta Keller, MD · PRINCIPAL_INVESTIGATOR · University California San Francisco
  • Rachel Hopper, MD · PRINCIPAL_INVESTIGATOR · Stanford University
  • Angela Bates, MD · PRINCIPAL_INVESTIGATOR · University of Alberta Edmonton
  • Catherine Avitabile, MD · PRINCIPAL_INVESTIGATOR · Children's Hospital of Philadelphia
  • Mary Mullen, MD · PRINCIPAL_INVESTIGATOR · Boston Children's Hospital
  • Eric Austin, MD · PRINCIPAL_INVESTIGATOR · Vanderbilt University Medical Center
  • Marc Natter, MD · PRINCIPAL_INVESTIGATOR · Boston Children's Hospital
  • Usha Krishnan, MD · PRINCIPAL_INVESTIGATOR · Columbia University
  • Lynn A Sleeper, ScD · PRINCIPAL_INVESTIGATOR · Boston Children's Hospital
  • Erika Rosenzweig, MD · PRINCIPAL_INVESTIGATOR · Maria Fareri Children's Hospital at WMC Health/Westchester Medical Center
  • Jenny Schramm, MD · PRINCIPAL_INVESTIGATOR · Johns Hopkins University
  • Lewis Romer, MD · PRINCIPAL_INVESTIGATOR · Johns Hopkins University
  • Grace Freire, MD · PRINCIPAL_INVESTIGATOR · Johns Hopkins All Children's Heart Institute
  • Stephanie Handler, MD · PRINCIPAL_INVESTIGATOR · Children's Hospital Wisconsin
  • Nidhy Varghese, MD · PRINCIPAL_INVESTIGATOR · Baylor College of Medicine
  • Russel Hirsch, MD · PRINCIPAL_INVESTIGATOR · Children's Hospital Medical Center, Cincinnati
  • Delphine Yung, MD · PRINCIPAL_INVESTIGATOR · Seattle Children's Hospital

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Eligibility criteria

Inclusion

The subject's age of onset of pulmonary hypertension must be prior to age 18 years
The person providing consent must be able to read either Spanish or English.
The subject (and/or parent/legal guardian) must be able to provide informed consent

Exclusion

Diagnosed with pulmonary hypertension after age 18
Refusal to sign informed consent
  • Time to clinical worsening12 months

    Time to clinical worsening for death, cardiac transplant, atrial septostomy, or Potts shunt.