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Understanding Vasculitis: An Observational Study

This study aims to better understand idiopathic systemic vasculitis, a group of diseases like Takayasu's Arteritis and Giant Cell Arteritis, where blood vessels become inflamed and damaged. Researchers want to learn more about the signs, symptoms, and genetic factors that influence these conditions. They are also looking for ways to predict how the disease might progress over time. You may be able to join if you are age 3 or older and have vasculitis, are suspected of having it, or are a healthy volunteer. This is an observational study, meaning no specific treatments are being tested; instead, researchers will gather information about your condition to help improve future care.

Study design
This is an observational study designed to enroll up to 4000 participants. It is not testing a specific intervention but rather collecting information about vasculitis.
What's involved
Participants will be evaluated by a doctor specializing in vasculitis and will provide a blood sample.
Compensation
Not stated in the trial record.
Follow-up
The primary goal is to study the disease's characteristics, measured at the end of the study. The duration of follow-up is not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT02257866

Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis

Recruiting
Not specifiedAges 3+Observational
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
~4,000 participants
Updated 2026-08-17 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
To study the pathogenesis of patients affected with idiopathic systemic vasculitis, including clinical, radiographic, immunological, and genetic characteristics of the disease
Measured over end of study

Conditions

Takayasu's Arteritis
Giant Cell Arteritis
Polyarteritis Nodosa
Relapsing Polychondritis
ANCA-Associated Vasculitis

Explore related trials

Eosinophilic Granulomatosis with PolyangiitisGiant Cell ArteritisGranulomatosis with PolyangiitisMicroscopic PolyarteritisPolyarteritis NodosaRelapsing PolychondritisSystemic vasculitisTakayasu Arteritis

Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • Peter C Grayson, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Who to contact

Shanni Liu
[email protected]
(240) 992-2440
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Subjects who fulfill modified versions of the 1990 American College of Rheumatology (ACR) Classification Criteria for GPA and PAN
Subjects who fulfill the 1990 ACR Classification Criteria for EGPA, GCA, and TAK
Subjects who fulfill the 2012 Chapel Hill Nomenclature definition for MPA
Subjects with other suspected systemic or single-organ vasculitides
Volunteers able to provide consent, or in the case of minors, assent

Exclusion

Subjects \< 3 years of age
Active malignancy, infection, or any medical condition that in the opinion of the investigator would warrant exclusion
Inability to provide consent, or in the case of minors, assent
Subjects with bleeding diathesis or on anticoagulant medications (e.g. coumadin, heparin, clopidogrel but not including aspirin or NSAIDs) are excluded from participation in nasal brushing or biopsy studies
Withdrawal of consent
Volunteers \< 3 years of age risk
Diagnosis of vasculitis or other autoimmune/autoinflammatory disease, including systemic lupus erythematosus, rheumatoid arthritis, sarcoidosis, mixed connective tissue disease or any overlap autoimmune syndrome
Active malignancy, infection, or any medical condition that in the opinion of the investigator would warrant exclusion
Pregnant (by history of last menstrual period) or breast-feeding subjects
Subjects with bleeding diathesis or taking anticoagulant medications (e.g. coumadin, heparin, clopidogrel but not including aspirin or NSAIDs) are excluded from participating in nasal brushing studies

What this trial measures

  • To study the pathogenesis of patients affected with idiopathic systemic vasculitis, including clinical, radiographic, immunological, and genetic characteristics of the diseaseend of study

    To study the pathogenesis of patients affected with idiopathic systemic vasculitis, including clinical, radiographic, immunological, and genetic characteristics of the disease