Hyperpolarized Xenon Gas for Lung Imaging in Children and Adults

This study is testing a new way to look at lung function using a special type of gas called hyperpolarized 129 Xenon (HP 129Xe) during an MRI scan. Researchers want to see if this method can accurately measure how well your lungs are working, both in healthy people and in those with breathing problems. You might be able to join if you are 6 years or older and can hold your breath for up to 16 seconds. You cannot join if you have certain heart conditions, are pregnant, or have uncontrolled asthma. The main goal is to compare the lung measurements from the HP 129Xe MRI with standard MRI results. The current recruitment status is unclear, but the study plans to enroll 300 participants.

Study design
This is an interventional study planning to enroll 300 participants aged 6 and up. It is not specified if it is randomized or blinded.
What's involved
You will inhale hyperpolarized Xenon gas for up to 16 seconds during up to four separate MRI scans on a single day. You will also have follow-up phone calls one day and 30 days after your MRI.
Compensation
Not stated in the trial record.
Follow-up
You will have follow-up phone calls one day and 30 days after your MRI date.

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NCT02272049

Use of Hyperpolarized Xenon Gas for Lung Imaging in Children and Adults

Recruiting
PHASE1Ages 6+InterventionalDiagnostic
Children's Hospital Medical Center, Cincinnati
~300 participants
Updated 2026-02-17 on ClinicalTrials.gov
What's tested:Hyperpolarized 129 Xenon

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Correlation of ventilated volume predictions obtained with 129Xe MRI vs. 1H MRI
Measured over Day 1
Respiratory Disorders
1 sites across 1 states
Ohio1
  • Jason C. Woods, PhD · PRINCIPAL_INVESTIGATOR · Children's Hospital Medical Center, Cincinnati

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Eligibility criteria

Inclusion

Ages 6 and up
Participant must be able to hold breath for up to 16 seconds

Exclusion

History of heart defect
Pregnancy or positive pregnancy test
History of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month
Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week
Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula
Participant is claustrophobic and unable to tolerate the imaging.
Standard MRI exclusions (metal, implants)
  • Correlation of ventilated volume predictions obtained with 129Xe MRI vs. 1H MRIDay 1

    quantify the measurement agreement between the ventilated volume of healthy lungs predicted via 129 Xe MRI and the ventilated volume of the pleural cavity predicted via proton MRI