MRI Assessment of Placental Health in Twin Pregnancies with IUGR
This observational study is looking at how the placenta works in pregnant mothers carrying twins, where one or both babies have Intrauterine Growth Restriction (IUGR), meaning they are smaller than expected. Researchers will use MRI scans to see how the placenta responds when the mother breathes extra oxygen for a short time. The goal is to understand how well the placenta is delivering oxygen to the babies, which could help doctors decide the best time for delivery to prevent stillbirth. You may be eligible if you are a pregnant woman between 18 and 45 years old with a twin pregnancy diagnosed with selective IUGR.
- Study design
- This is an observational study with a planned enrollment of 80 participants. It is not a randomized trial.
- What's involved
- You would receive oxygen for no more than 10 minutes during a 1-hour MRI scan. This administration would happen once per scan.
- Compensation
- Not stated in the trial record.
- Follow-up
- The study measures changes during the 1-hour scan, specifically at 5 minutes and 30 minutes. No longer-term follow-up is specified.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
MRI Assessment of Placental Health
At a glance
Conditions
Where it's being run
2 sites across 2 statesStudy leadership
- Patricia E Grant, MD · PRINCIPAL_INVESTIGATOR · Boston Children's Hospital
Who to contact
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Do you actually qualify for this trial?
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Inclusion
What this trial measures
- BOLD MRI signal change during maternal oxygen exposure in placenta and fetus30 min during the 1 hour scan
- placental volume on MRI image5 min during 1 hour scan