This study aims to better understand microvascular coronary dysfunction (MCD), a condition where small heart blood vessels don't work properly, causing chest pain, mainly in women. Researchers believe MCD affects how the heart relaxes. This study will involve 30 women, including those with MCD and healthy volunteers. To learn more about MCD, participants will undergo activities like handgrip exercises, altitude simulation (breathing lower oxygen), and leg exercises. The main goal is to see how these activities affect heart relaxation, measured by MRI 24 hours later. The study is currently unclear on its recruitment status.

Study design

This interventional study plans to enroll 30 women, including 10 with microvascular disease, 10 healthy individuals, and 10 age-matched women.

What's involved

Participants will perform handgrip exercises, breathe lower concentrations of oxygen to simulate altitude, and do leg exercises. Diastolic function will be measured by MRI at 24 hours.

Compensation

Not stated in the trial record.

Follow-up

Diastolic function will be measured by MRI at 24 hours after the interventions.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.