This study is looking at whether a medicine called tranexamic acid, applied directly to the surgical area, can help reduce blood loss during spine surgery. Researchers want to see if using tranexamic acid (TXA) can lower the amount of blood lost during and after surgery, reduce the need for blood transfusions, and potentially lower the risk of infection. You might be able to join if you are between 18 and 80 years old, need surgery for a thoracic or lumbar spinal injury within 21 days, or are having a long spinal fusion surgery (more than 5 levels). The main goal is to see if TXA reduces the biggest drop in your blood's hemoglobin (a protein in red blood cells) level after surgery. The current status of this study is unclear, and it aims to enroll 252 participants.

Study design

This is a randomized, double-blind, placebo-controlled study, meaning participants will be randomly assigned to receive either tranexamic acid or a placebo, and neither you nor your doctors will know which you receive. It involves patients undergoing posterior spinal fusion or complex deformity surgery.

What's involved

You would receive either tranexamic acid or a placebo poured into the surgical field during your spine surgery. The solution will be left in contact for five minutes, then suctioned away before the wound is closed.

Compensation

Not stated in the trial record.

Follow-up

You will be followed through postoperative day 4 to measure the maximal drop in systemic hemoglobin concentration.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.