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Hyperpolarized 129Xenon MRI for Lung Imaging

This study is testing how well a special type of MRI, called hyperpolarized (HP) 129Xenon MRI, can measure lung function in healthy adults. Researchers want to see if the predictions of lung volume from 129Xenon MRI match those from standard MRI. You would inhale 129Xenon gas during up to four MRI scans, holding your breath for up to 16 seconds each time. This study is for adults aged 18 and older who can hold their breath for 16 seconds. You cannot participate if you have a heart defect, are pregnant, or have uncontrolled asthma. The study is currently recruiting about 100 participants.

Study design
This interventional study plans to enroll about 100 adult participants. It is not specified if it is randomized or blinded.
What's involved
You would have one imaging session on a single day, involving up to four MRI scans where you inhale 129Xenon gas and hold your breath for up to 16 seconds. Conventional proton MR images may also be taken.
Compensation
Not stated in the trial record.
Follow-up
You will have follow-up appointments one day and 30 days after your MRI date.

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NCT02316379

Use of Hyperpolarized 129Xe MR Lung Imaging in Adults for Calibration

Recruiting
PHASE1Ages 18+InterventionalDiagnostic
Children's Hospital Medical Center, Cincinnati
~100 participants
Updated 2025-09-10 on ClinicalTrials.gov
What's tested:Hyperpolarized 129 XenonMRI

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Correlation of ventilated volume predictions obtained with 129Xe MRI vs. 1H MRI
Measured over Day 1

Conditions

Respiratory Disorders

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Respiratory System Disorder

Where it's being run

1 sites across 1 states
Ohio1

Study leadership

  • Jason C Woods, Ph.D. · PRINCIPAL_INVESTIGATOR · Children's Hospital Medical Center, Cincinnati

Who to contact

Carrie Stevens, BS
[email protected]
513-636-9973
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Adults ages 18 years and older
Participant must be able to hold their breath for up to 16 seconds

Exclusion

History of heart defect
Pregnancy or positive pregnancy test
History of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month.
Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week.
Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula.
Participant is claustrophobic and unable to tolerate the imaging.
Standard MRI exclusions (metal, implants).

What this trial measures

  • Correlation of ventilated volume predictions obtained with 129Xe MRI vs. 1H MRIDay 1

    quantify the measurement agreement between the ventilated volume of healthy lungs predicted via 129 Xe MRI and the ventilated volume of the pleural cavity predicted via proton MRI