Adaptive Optics Retinal Imaging for Eye Diseases

This observational study is looking at a special way to take pictures of the eye called adaptive optics (AO) imaging. Researchers want to see if AO imaging can help find eye diseases earlier and improve how doctors diagnose and manage them. They are comparing AO images from people with eye diseases to those from healthy volunteers. You might be able to join if you are 12 years or older and can cooperate with an eye exam. The study aims to understand what success looks like by comparing the AO images from healthy eyes to those with disease.

Study design: This is an observational study that plans to enroll 1000 participants, including people with eye diseases and healthy volunteers.
What's involved: You will have at least one study visit, which includes a medical and eye history, questions about your medications, an eye exam with pupil dilation, and adaptive optics imaging.
Compensation: Not stated in the trial record.
Follow-up: The primary endpoint, qualitative and quantitative assessment of AO images, is measured at ongoing, so follow-up duration is not specified.

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Adaptive Optics Retinal Imaging

Recruiting

Not specifiedAges 12+Observational

National Eye Institute (NEI)

~1,000 participants

Updated 2026-08-10 on ClinicalTrials.gov

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Qualitative and quantitative assessment of AO images

Measured over ongoing

Conditions

Eye Diseases

Healthy Volunteers

Where it's being run

1 sites across 1 states

Maryland1

Study leadership

Johnny C Tam, Ph.D. · PRINCIPAL_INVESTIGATOR · National Eye Institute (NEI)

Who to contact

Daniel W Claus, R.N.

[email protected]

(301) 451-1621

Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Are 12 years of age or older.

Have the ability to cooperate with an eye exam and adaptive optics imaging.

Have the ability to understand and sign an informed consent or have a parent/legal guardian to do so if they are minor children.

Have an eye disease or are a healthy volunteer with a normal eye exam (no visually-significant eye findings on examination).

Exclusion

They have a condition which prevents adequate images from being obtained (e.g. unstable fixation or media opacity).

Are under 18 years of age.

For participants who will undergo fluorescein imaging have a history of adverse reaction to fluorescein.

For participants who will undergo indocyanine green imaging have a history of adverse reaction to indocyanine green dye, know or suspected allergies to iodine or shellfish.

What this trial measures

Qualitative and quantitative assessment of AO imagesongoing
Qualitative and quantitative assessment of AO images with comparison of normal and diseased states.

Trialytics