This study is looking at how different doses of phenylephrine hydrochloride injection affect blood pressure in teenagers (ages 12-16) who experience low blood pressure during surgery. Researchers want to understand how much phenylephrine is needed to treat low blood pressure, how quickly it works, and how long its effects last. They will also check the safety of phenylephrine in this age group and how the body processes the medication. You may be eligible if you are between 12 and 16 years old, are scheduled for surgery requiring general or neuraxial anesthesia, and have generally good health. The study aims to enroll 100 participants, but up to 300 may be enrolled to ensure enough participants experience low blood pressure during surgery and receive the study drug. The study's current status is unclear.

Study design

This is a Phase 4, multi-center, randomized, open-label study involving 100 subjects. Participants will receive one of six initial treatments of phenylephrine hydrochloride injection, either as an intravenous bolus (quick injection) or a continuous intravenous infusion (drip).

What's involved

Not specified in the trial record.

Compensation

Not stated in the trial record.

Follow-up

Plasma phenylephrine concentrations will be measured from screening up to Day 3.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.