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Understanding Diseases Affecting Salivary Glands

This observational study aims to better understand diseases that affect your salivary glands, which produce saliva in your mouth and throat. Researchers will collect information and samples from people with salivary gland problems, their family members, and healthy volunteers. This will help them learn more about these conditions and their genetic links. The study is open to people aged 4 to 100 years old who have or are suspected of having a salivary gland disease, or who are relatives of someone with such a disease. Healthy volunteers aged 18 or older are also welcome. The study is also looking at people with active hepatitis or those receiving immunotherapy with an immune checkpoint inhibitor. The goal is to generate new ideas for future research.

Study design
This is an observational study planning to enroll 1150 participants, including healthy volunteers, individuals with Sjogren's Syndrome, and those with other salivary gland diseases.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT02327884

Characterization of Diseases With Salivary Gland Involvement

Recruiting
Not specifiedAges 4+Observational
National Institute of Dental and Craniofacial Research (NIDCR)
~1,150 participants
Updated 2026-08-28 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
hypothesis generating
Measured over hypothesis generating

Conditions

Healthy Volunteer
Sjogren's Syndrome
Salivary Gland Disease

Explore related trials

Healthy VolunteerHepatitisLip and Oral Cavity CarcinomaSalivary Gland DisorderSjogren Syndrome

Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • Margaret E Beach, P.A.-C · PRINCIPAL_INVESTIGATOR · National Institute of Dental and Craniofacial Research (NIDCR)

Who to contact

Eileen M Pelayo
[email protected]
(301) 594-3097
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Persons older than 4 years of age, affected with or suspected of being affected with a disease/disorder involving the salivary glands or who is a relative of a person who is affected with these diseases/disorders.

Exclusion

Anyone not able to give consent/assent or parental/guardian consent
NIH employees who report directly to the principal investigator
Significant concurrent medical condition or other circumstances that may affect the participant s ability to tolerate or complete the study, such as concurrent chemotherapy or bleeding disorders.
Moreover, these immune checkpoint inhibitor subjects, if unable to tolerate the study procedures, such as salivary gland biopsies, saliva collections, and/or oral exams, will be excluded as determined by the Principal Investigator.
Pregnancy
Sicca Symptoms
HIV, hepatitis B or C infection
Chronic medical illness, other than well-controlled hypertension or hyperlipidemia
Chronic use of medications, with the exception of oral contraception, hormone replacement therapy, aspirin, antihypertensives and antilipemics

What this trial measures

  • hypothesis generatinghypothesis generating

    hypothesis generating