Lovenox Dosing Comparison for Blood Clot Prevention

This study is comparing two different ways of giving enoxaparin (Lovenox), a medicine used to prevent blood clots. You might be eligible if you are an admitted patient over 15 years old, needing Lovenox for trauma or surgery. The study aims to see if giving 30 mg of Lovenox twice a day is better or worse than 40 mg once a day at preventing blood clots (thromboembolic events) and if one dose causes more bleeding. Researchers will check for blood clots daily for up to 90 days. The study's current status is unclear, and it plans to enroll 606 patients.

Study design
This is a prospective, randomized study at a single center, comparing two different doses of enoxaparin. It plans to enroll 606 participants.
What's involved
You would be randomized to receive either 30 mg of enoxaparin twice daily or 40 mg once daily. You would also undergo weekly ultrasound duplex examinations of your lower extremities.
Compensation
Not stated in the trial record.
Follow-up
Researchers will measure thromboembolic events daily, up to 90 days.

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NCT02342444

Lovenox 30 mg Twice Daily (BID) Versus 40 mg Once Daily (QD)

UNKNOWN
PHASE4Ages 15+InterventionalPrevention
Oregon Health and Science University
~606 participants
Updated 2024-04-03 on ClinicalTrials.gov
What's tested:Enoxaparin Sodium Injection 30 mg BIDEnoxaparin Sodium Injection 40 mg QD

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Thromboembolic events
Measured over Daily, up to Day 90
Trauma
Surgery
Deep Vein Thrombosis (DVT)
Thromboembolic Events
1 sites across 1 states
Oregon1
  • Martin A Schreiber, MD · PRINCIPAL_INVESTIGATOR · Oregon Health and Science University

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Eligibility criteria

Inclusion

Admitted patients requiring prophylactic dosing of enoxaparin (Lovenox)
Admitted to the trauma or surgical service
Age greater than 15 years

Exclusion

Unable to obtain consent from patient or authorized representative
Presence of intracranial hemorrhage
Receiving therapeutic dose of enoxaparin (Lovenox)
Receiving other forms of anticoagulation
Presence of renal failure requiring non-standard dosing regimen
  • Thromboembolic eventsDaily, up to Day 90

    Daily monitoring per standard of care for the development of thromboembolic events.