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Observational Study of Intra-Uterine Growth Restriction (IUGR)

This study is looking at babies diagnosed with Intra-Uterine Growth Restriction (IUGR), a condition where a baby in the womb doesn't grow as expected. Researchers will use special imaging like ultrasound and MRI (magnetic resonance imaging) to get detailed pictures of the baby's brain, heart, and the placenta (the organ that provides nutrients to the baby). They will also collect blood samples from the mother and umbilical cord, and analyze the placenta after birth. Later, they will assess the baby's neurological development using tests like the Bayley and Mullen exams. The goal is to understand how IUGR affects babies over time and improve how doctors diagnose and treat this condition. You may be able to join if you are a woman between 18 and 45 years old and your baby has been diagnosed with IUGR.

Study design
This is an observational study planning to enroll 200 participants. It will follow participants over time to see how IUGR progresses.
What's involved
You would undergo frequent ultrasounds and MRIs, have blood collected, and your baby would have neurological assessments and placental analysis.
Compensation
Not stated in the trial record.
Follow-up
The primary goal is to characterize events defining IUGR pathogenesis, measured every two weeks from diagnosis or first visit.

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NCT02382601

Longitudinal Study of Intra-Uterine Growth Restriction

Recruiting
Not specifiedAges 18–45Observational
University of Colorado, Denver
~200 participants
Updated 2026-06-11 on ClinicalTrials.gov
What's tested:UltrasoundMRIBlood collectionNeurological Function AssessmentPlacental AnalysisMeasurement of body fat

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Characterize the sequence of neurological and cardiovascular events defining early and late IUGR pathogenesis, respectively
Measured over Every two weeks from the time of IUGR diagnosis or first visit

Conditions

IUGR
Pregnancy

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Fetus Small for Gestational AgeSmall for Gestational Age

Where it's being run

1 sites across 1 states
Colorado1

Study leadership

  • John Hobbins, MD · PRINCIPAL_INVESTIGATOR · University of Colorado, Denver

Who to contact

Emma Peek, BS
[email protected]
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patients with diagnosed SGA by an ultrasound estimated fetal weight (EFW) of less than the 10th percentile or a fetal abdominal circumference of less than the 5th percentile will be included in the study at the time of their first examination.

Exclusion

Patients \< 18 years of age, and chromosomal anomalies as identified by regular aneuploidy screening.

What this trial measures

  • Characterize the sequence of neurological and cardiovascular events defining early and late IUGR pathogenesis, respectivelyEvery two weeks from the time of IUGR diagnosis or first visit

    Using ultrasound and MRI to identify changes in the fetal vasculature, and fetal brain as early and late IUGR progress.