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Observational Study on High Altitude and Pregnancy

This study is looking at how living at high altitude during pregnancy might affect blood vessels in the uterus. Researchers want to understand why problems like intrauterine growth restriction (IUGR), where a baby doesn't grow as expected, and preeclampsia (PreE), a serious blood pressure condition, are more common at high altitudes. They will collect tissue samples (from the uterus, umbilical cord blood, and placenta) from women having C-sections at hospitals in Denver (lower altitude) and Summit County (higher altitude). By comparing these samples, they hope to see if altitude changes how these blood vessels react. This information could help us better understand and treat IUGR and preeclampsia.

Study design
This is an observational study planning to include 84 women. It compares women living at high altitude to those at lower altitude.
What's involved
If you participate, researchers will collect samples of your uterine tissue, cord blood, and placenta during your scheduled C-section.
Compensation
Not stated in the trial record.
Follow-up
Changes in uterine artery dimensions will be measured for up to 1 year.

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NCT02391519

Effects of High Altitude on AMPK Activation

Recruiting
Not specifiedAges 18–45Observational
University of Colorado, Denver
~84 participants
Updated 2026-02-13 on ClinicalTrials.gov
What's tested:Collection of myometrial, cord blood, and placental tissue samples

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Changes in Myometrial artery dimensions
Measured over Up to 1 year

Conditions

Pregnancy
IUGR
Preeclampsia

Explore related trials

Pregnancy

Where it's being run

1 sites across 1 states
Colorado1

Study leadership

  • Lorna Moore, PhD · PRINCIPAL_INVESTIGATOR · University of Colorado, Denver

Who to contact

Lorna Moore, PhD
[email protected]
303-724-7474
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Women scheduled for cesarean delivery at University of Colorado Hospital (Denver, 1600 m) and St. Anthony's Summit Medical Center (Summit County, 3000 m)
Cesarean delivery at a prescheduled time without any labor, typically at 39 weeks gestation

Exclusion

Women will be excluded if there are co-existing medical diagnoses that are known to affect vascular parameters (i.e., diabetes mellitus, gestational diabetes, any hypertensive disorder of pregnancy, or a current smoker).
Women with multiple gestations and preterm deliveries will also be excluded.

What this trial measures

  • Changes in Myometrial artery dimensionsUp to 1 year

    Myometrial artery dimensions as quantified by immunohistochemistry or other staining techniques, and results of studies of isolated myometrial artery studies in which vasoconstrictor and vasodilator responses to pharmacological agonists are measured using absolute values and the percent maximal contraction to potassium chloride.