This study is testing different ways to give hyperbaric oxygen (HBO) treatment for severe traumatic brain injury (TBI). HBO involves breathing pure oxygen in a special pressurized room. Researchers want to find the best combination of oxygen pressure (1.5, 2.0, or 2.5 ATA) and whether adding NBH (a specific treatment given after HBO) improves recovery. You might be able to join if you are 16-65 years old and have a severe TBI. The main goal is to see if these treatments improve your recovery, measured by a scale called the Glasgow Outcome Scale Extended (GOS-E) six months after treatment. The study is currently unclear on its status and plans to enroll 200 participants.

Study design

This is an interventional study planning to enroll 200 participants. It is designed to compare several different hyperbaric oxygen treatment approaches.

What's involved

Participants will receive hyperbaric oxygen treatment twice a day for five days, or until they are following commands or brain dead. Some treatments will also include NBH for 3 hours after the HBO session.

Compensation

Not stated in the trial record.

Follow-up

Your recovery will be assessed at 6 months after treatment using the Glasgow Outcome Scale Extended (GOS-E).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.