This study is looking into why people with chronic kidney disease (CKD) have trouble exercising and experience increased blood pressure during physical activity. Researchers want to understand if problems with blood vessel widening or narrowing play a role. You might be eligible if you are a veteran aged 18-75 with Stage III or IV CKD, a kidney transplant recipient, or a veteran without kidney disease who exercises less than twice a week. The study is testing if taking Sodium Bicarbonate tablets or a placebo (an inactive pill) before exercise or stretching can help. The main goals are to see how these interventions affect muscle oxygen, muscle pH (acidity), and blood vessel narrowing after 12 weeks. The current status of the study is unclear, and it plans to enroll 110 participants.

Study design

This is an interventional study that plans to enroll 110 participants. It compares different interventions like Sodium Bicarbonate, placebo, exercise training, and stretching.

What's involved

Participants will take Sodium Bicarbonate or a placebo before exercise or stretching sessions, 3 times per week for 6-12 weeks. Serum bicarbonate levels will be monitored regularly.

Compensation

Not stated in the trial record.

Follow-up

Changes in muscle oxygenation, muscle pH, and venoconstriction will be measured at 12 weeks after the start of the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.