Polarization Sensitive Optical Coherence Tomography (PS-OCT) for Retinal Imaging

This study is testing a new way to take pictures of the eye called Polarization-Sensitive OFDI (PS-OCT). Researchers want to see if this new imaging device can get clear pictures of something called retinal birefringence, which is a property of the nerve fibers in your eye. Glaucoma, a leading cause of blindness, affects these nerve fibers. Current tests for glaucoma often only find the disease after a lot of damage has already happened. This new PS-OCT method aims to detect changes in these nerve fibers earlier. You might be able to join if you are between 18 and 85 years old, have generally healthy eyes (except for mild cataracts), and have clear enough vision for imaging. The main goal is to measure the average nerve fiber layer (NFL) birefringence at the time of imaging.

Study design
This is an interventional study, meaning participants will receive a specific intervention (OCT imaging). It plans to enroll 20 healthy participants.
What's involved
Participants will undergo OCT imaging of their eye at the time of enrollment.
Compensation
Not stated in the trial record.
Follow-up
The primary measurement is taken at the time of imaging, so there is no specified long-term follow-up.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT02441777

Polarization Sensitive Optical Coherence Tomography (PS-OCT) for Retinal Imaging

Not Yet Recruiting
NAAges 18–85InterventionalDevice feasibility
Massachusetts General Hospital
~20 participants
Updated 2025-12-09 on ClinicalTrials.gov
What's tested:Polarization-Sensitive OFDI

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Average nerve fiber layer (NFL) birefringence
Measured over At time of imaging
Healthy
1 sites across 1 states
Massachusetts1
  • Benjamin Vakoc, Ph.D. · PRINCIPAL_INVESTIGATOR · Massachusetts General Hospital

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  • Average nerve fiber layer (NFL) birefringenceAt time of imaging

    Measured birefringence values will be compared to normative values from literature