Hand Transplantation for Amputation

This study is investigating hand transplantation, a surgery that transfers tissue from a non-living donor to a living individual. The goal is to see if this procedure can help people who have lost all or part of one or both hands and forearms regain better function, appearance, and feeling. Researchers will also collect information on how patients recover and what their outcomes are after the transplant. You may be able to join if you are between 18 and 60 years old, are missing part of your hand or forearm due to injury, and are HIV negative. The study will measure how many people experience biopsy-proven rejection (when the body's immune system attacks the new hand) over 60 months.

Study design: This is an interventional study planning to enroll 100 participants. It is designed to evaluate the effects of hand transplantation.
What's involved: You would undergo pre-transplant screening procedures and evaluations, which are re-evaluated yearly if you are on the waiting list. If on the waitlist, you would provide serum samples monthly for cross-matching.
Compensation: Not stated in the trial record.
Follow-up: Participants will be followed for 60 months to monitor for biopsy-proven rejection.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Hand Transplantation

Withdrawn

NAAges 18–60Interventional

NYU Langone Health

Updated 2026-08-31 on ClinicalTrials.gov

What's tested:Hand Transplantation

At a glance

Recruiting sites

0 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Number and proportion of subjects with biopsy-proven rejection

Measured over 60 months

Conditions

Amputation

Where it's being run

1 sites across 1 states

New York1

Study leadership

Sheel Sharma, MD · PRINCIPAL_INVESTIGATOR · NYU Langone Medical Center

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime

Eligibility criteria

Inclusion

Candidates may be male or female patients between the ages of 18 and 60 who are missing all or part of one or both hands and forearms

Must be HIV negative at the time of transplant

Crossmatch is negative between donor and recipient

Women who are of child bearing potential must have a negative pregnancy test (urine test is acceptable) within 48 hours of transplant and agree to use reliable contraception for one year following transplant

Subjects must give written informed consent

Subjects who are poor candidates for prosthesis and eligible for hand transplant - prosthesis failure or non acceptance/poor satisfaction with trial of prosthesis

Exclusion

Uncontrolled infection or severe concomitant diseases which would exclude the recipient from transplantation

Substance abuse disorders not currently under control (as determined by the Michigan Alcohol Screening Test)

Active severe psychiatric illness such as Psychosis or Depression

Body Dysmorphic disorder (see Appendix K for screening tool). Less severe psychiatric conditions are addressed on a case by case basis

Co-existing medical or psycho-social problems relevant to tissue allotransplantation:

Positive serology for HIV; Hepatitis B/C Antigen

Subjects with any cognitive deficits related to a TBI (traumatic brain injury) and or any organic neurological disorders

Active malignancy within 5 years

Unstable social situation as evidenced by lack of stable housing and/or lack of a supportive significant other

Cognitive limitations affecting patients ability

Recent history of medical nonadherence

Any other psychological status that would hinder the success or safety of the transplantation.

Level of amputation proximal to mid-humerus: some presence of proximal muscles is required to motor a functioning hand

Congenital Abnormalities: co-existent absence/atrophy/agenesis of any tissue may affect post transplant results

History of amputation of less than six months: subject must be allowed to attempt prosthetic use prior to hand transplantation. This can be waived in cases where the recipient requires amputation/revision of the transplant site at the time of transplantation. However, if at all possible it is highly encouraged that the patient has ruled out prosthetics as an alternative to transplantation.

Blindness: blind amputees may be poor candidates because sensory return in the hand may not provide sufficient protective sensation

Pregnancy

What this trial measures

Number and proportion of subjects with biopsy-proven rejection60 months

Trialytics