This study aims to better understand the brain changes that happen when someone has thought about or attempted suicide. Researchers will use brain imaging (Magnetic Resonance Imaging scanner, 3T and 7T), pupillometers (NeurOptics PLRTM-3000 Pupillometer) to measure pupil size, and devices to test anxiety responses (Experimental Anxiety Devices). They will also use Ketamine Hydrochloride, a drug that affects brain receptors. The study will compare people who have thought about or attempted suicide with those who have depression or anxiety, and healthy volunteers. Success will be measured by looking at differences in psychiatric, psychological, brain imaging, sleep, and biological markers, as well as changes in suicide thoughts and depression symptoms over time. The study is currently unclear on its recruitment status and plans to enroll 325 participants.

Study design

This is an interventional study with an unclear status, planning to enroll 325 participants across five groups, including healthy volunteers and individuals with depression or a history of suicidal thoughts/attempts.

What's involved

Participants will undergo various tests and examinations, including brain imaging, pupillometer measurements, anxiety response tests, and potentially receive Ketamine Hydrochloride. Specific details on the number of visits or duration are not provided.

Compensation

Not stated in the trial record.

Follow-up

Psychiatric, psychological, neuroimaging, sleep, and biological differences will be measured at multiple time-points. Suicide ideation and depression ratings will also be measured at multiple time-points.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.