Observational Study on Biomarkers in Infection

This study is looking at how well certain biological markers (biomarkers) can identify patients with infections like sepsis (a life-threatening response to infection) and inflammation who are at risk for poor outcomes. Researchers are interested in understanding how the body's immune system responds to infection. They are comparing current tests like white blood cell counts with other potential markers, including VEGF (Vascular Endothelial Growth Factor) and other inflammatory markers, to see if these can provide earlier and better information for doctors. The study aims to enroll 4200 participants, including adults aged 18 and older with confirmed or suspected infections, and a control group of adults without infection who have normal white blood cell counts and body temperature. The main goal is to see how these biomarkers relate to whether a patient dies in the hospital within 28 days of joining the study. The study's current recruitment status is unclear.

Study design
This is an observational study, meaning researchers will collect information without giving any specific treatments. It plans to include 4200 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 28 days after joining the study to assess in-hospital mortality.

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NCT02545478

Biomarkers in Infection

Recruiting
Not specifiedAges 18+Observational
Beth Israel Deaconess Medical Center
~4,200 participants
Updated 2026-04-15 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
28 day in-hospital mortality
Measured over within 28 days after inclusion
Sepsis
Infection
Inflammation
2 sites across 1 states
Massachusetts2
  • Nathan Shapiro, MD MPH · PRINCIPAL_INVESTIGATOR · Beth Israel Deaconess Medical Center

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Eligibility criteria

Inclusion

Age 18 years of age or older
Confirmed or suspected infection
Age 18 years of age or older
A non-infectious clinical presentation to include
Normal white blood cell count ( \> 4,000 and/or \< 12,000)
Normothermia ( \> 96.5 and/or less 100.4)
Absence of the following clinical complaints: productive cough, fever, pyuria, rash
No evidence of acute coronary syndrome
  • 28 day in-hospital mortalitywithin 28 days after inclusion

    participants will be followed up for 28 days