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NCT02553525

Effects of Stimulation Patterns of Deep Brain Stimulation

Enrolling by Invitation
NAAges 21–80InterventionalBasic science
Duke University
~180 participants
Updated 2026-04-09 on ClinicalTrials.gov
What's tested:Therapeutic Stimulation PatternsSymptogenic Stimulation Patterns

At a glance

Recruiting sites
0 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Tremor Accelerometry
Measured over Day 1
+2 more outcomes measured

Conditions

Parkinson Disease
Essential Tremor
Multiple Sclerosis
Dystonia

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DystoniaEssential TremorMultiple SclerosisParkinson Disease

NCT02553525

Where you'd take part

This study runs at 3 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Duke University

    Durham, North Carolinano site contact published

  • Emory University

    Atlanta, Georgiano site contact published

  • University of Florida

    Gainesville, Floridano site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Warren M Grill, PhD · PRINCIPAL_INVESTIGATOR · Duke University

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

Diagnosis of Parkinson's Disease (PD), Essential Tremor (ET) dystonia or Multiple Sclerosis (MS)
Scheduled to undergo Deep Brain Stimulation (DBS) electrode implant, IPG implant or implanted pulse generator (IPG) replacement surgery
Neurologically stable
Able to understand the study and consent form

Exclusion

Inability to execute the motor tasks during the study
Inability to tolerate withholding anti-parkinsonian and/or anti-tremor medications
Clinically ineffective DBS

What this trial measures

  • Tremor AccelerometryDay 1

    Tremor responses to deep brain stimulation (DBS) may be recorded by an accelerometer in subjects with essential tremor (ET), multiple sclerosis (MS) and tremor-dominant Parkinson's disease (PD). Tremor will be quantified by calculating the total power within a window of the power spectrum of the time series of the tremor, and this measure will be compared across stimulation patterns.

  • Bradykinesia Finger TappingDay 1

    Bradykinesia responses to deep brain stimulation (DBS) may be recorded by a computer mouse in subjects with Parkinson's disease (PD) who do not have dominant tremor symptoms. Bradykinesia will be quantified as the timing of alternating finger presses, a validated test of bradykinesia, and this measure will be compared across stimulation patterns.

  • Neural ActivityDay 1

    Neural activity consisting of electrically evoked compound action potentials (ECAPs), DBS local evoked potentials (DLEPs) and/or local field potentials (LFPs) may be recorded in response to deep brain stimulation (DBS). Neural activity characteristics will be compared across stimulation patterns and may be correlated with changes in severity of motor symptoms (tremor or bradykinesia).