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NCT02553525

Effects of Stimulation Patterns of Deep Brain Stimulation

Enrolling by Invitation
NAAges 21–80InterventionalBasic science
Duke University
~180 participants
Updated 2026-04-09 on ClinicalTrials.gov
What's tested:Therapeutic Stimulation PatternsSymptogenic Stimulation Patterns

At a glance

Recruiting sites
0 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Tremor Accelerometry
Measured over Day 1
+2 more outcomes measured

Conditions

Parkinson Disease
Essential Tremor
Multiple Sclerosis
Dystonia

Explore related trials

DystoniaEssential TremorMultiple SclerosisParkinson Disease

Where it's being run

3 sites across 3 states
Florida1
Georgia1
North Carolina1

Study leadership

  • Warren M Grill, PhD · PRINCIPAL_INVESTIGATOR · Duke University

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Diagnosis of Parkinson's Disease (PD), Essential Tremor (ET) dystonia or Multiple Sclerosis (MS)
Scheduled to undergo Deep Brain Stimulation (DBS) electrode implant, IPG implant or implanted pulse generator (IPG) replacement surgery
Neurologically stable
Able to understand the study and consent form

Exclusion

Inability to execute the motor tasks during the study
Inability to tolerate withholding anti-parkinsonian and/or anti-tremor medications
Clinically ineffective DBS

What this trial measures

  • Tremor AccelerometryDay 1

    Tremor responses to deep brain stimulation (DBS) may be recorded by an accelerometer in subjects with essential tremor (ET), multiple sclerosis (MS) and tremor-dominant Parkinson's disease (PD). Tremor will be quantified by calculating the total power within a window of the power spectrum of the time series of the tremor, and this measure will be compared across stimulation patterns.

  • Bradykinesia Finger TappingDay 1

    Bradykinesia responses to deep brain stimulation (DBS) may be recorded by a computer mouse in subjects with Parkinson's disease (PD) who do not have dominant tremor symptoms. Bradykinesia will be quantified as the timing of alternating finger presses, a validated test of bradykinesia, and this measure will be compared across stimulation patterns.

  • Neural ActivityDay 1

    Neural activity consisting of electrically evoked compound action potentials (ECAPs), DBS local evoked potentials (DLEPs) and/or local field potentials (LFPs) may be recorded in response to deep brain stimulation (DBS). Neural activity characteristics will be compared across stimulation patterns and may be correlated with changes in severity of motor symptoms (tremor or bradykinesia).