The Effects of Sleep on Human Microbiota

This study is looking at how sleep affects the human microbiota (the community of tiny living things in and on your body). Researchers believe that changes in your microbiota might show up before you get sick, and could help predict when a disease might start or how well a treatment is working. This study will explore if your microbiota is changed by sleep restriction (getting less sleep) and weight gain. They want to see if these changes in microbiota are linked to health risks. The study aims to enroll 5000 healthy adults, aged 18 and older, who are already eligible for other approved studies. The goal is to see how your microbiota changes after one year due to sleep changes, and after 20 weeks due to changes in body weight and sleep.

Study design
This is an interventional study with a planned enrollment of 5000 participants. It is not specified if it is randomized or blinded.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for changes in microbiota for up to one year, and for 20 weeks regarding changes related to body weight and sleep.

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NCT02573753

The Effects of Sleep on Human Microbiota: Implications for Health and Disease

Recruiting
NAAges 18+InterventionalPrevention
Mayo Clinic
~5,000 participants
Updated 2026-08-04 on ClinicalTrials.gov
What's tested:Sleep restrictionWeight gain

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Changes in human microbiota induced by sleep manipulation in healthy subjects
Measured over 1 year
+1 more outcome measured
Sleep
1 sites across 1 states
Minnesota1
  • Virend Somers, MD, PhD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

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Eligibility criteria

Inclusion

Only subjects who are eligible for ongoing IRB-approved studies will be deemed eligible for this protocol.

Exclusion

Pregnant or breast-feeding women
Subjects who are ineligible for ongoing IRB-approved studies will not be included in this protocol
  • Changes in human microbiota induced by sleep manipulation in healthy subjects1 year
  • Changes in human microbiota induced by fluctuations in body weight and sleep in healthy subjects20 weeks