Study on Suicidal Behavior in Bipolar Disorder

This study is looking into environmental and psychological factors that contribute to suicidal thoughts and behaviors in people with Bipolar Disorder. It also aims to find effective treatments to reduce these behaviors and improve quality of life. You might be eligible if you are 18-64 years old, speak English, and have a diagnosis of Bipolar Disorder. The study is testing four different group-based therapies: Interpersonal and Social Rhythm Therapy (ISRT), Bipolar-Specific Cognitive Behavioral Therapy (CBT), Mindfulness-Based Stress Reduction (MBSR), and Psycho-education & Understanding Bipolar Medications Therapy. The main goal is to see how these therapies affect suicidal thoughts and behaviors, measured by a scale called the Columbia-Suicide Severity Rating Scale (C-SSRS) score. The current recruitment status is unclear.

Study design
This is an interventional study with a planned enrollment of 130 participants. It is not specified if the study is randomized or blinded.
What's involved
You would participate in one of four group-based interventions, attending sessions once a week for six weeks. Each session would last 55-60 minutes.
Compensation
Not stated in the trial record.
Follow-up
Your suicidal thoughts and behaviors will be measured before the intervention and up to six weeks after the intervention.

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NCT02604277

Suicidal Behavior in Patients Diagnosed With Bipolar Disorder

Recruiting
NAAges 18–64InterventionalTreatment
Emory University
~130 participants
Updated 2026-01-07 on ClinicalTrials.gov
What's tested:Interpersonal and Social Rhythm Therapy (ISRT)Bipolar-Specific Cognitive Behavioral Therapy (CBT)Mindfulness-Based Stress Reduction (MBSR)Psycho-education & Understanding Bipolar Medications Therapy

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Columbia-Suicide Severity Rating Scale (C-SSRS) Score
Measured over Pre-intervention, Post-intervention (Up to six weeks)
Depression
Alcoholism
Drug Abuse
1 sites across 1 states
Georgia1
  • Dorian Lamis, PhD · PRINCIPAL_INVESTIGATOR · Emory University

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Eligibility criteria

Inclusion

English speaking
Diagnosis of Bipolar Disorder (BD)
Able to provide written informed consent

Exclusion

Cognitive impairments
Acutely psychotic
Medically unstable
History of schizophrenia spectrum disorder
History of mood incongruent psychotic symptoms
History of primary substance disorder
History of primary organic disease and/or dementia
  • Columbia-Suicide Severity Rating Scale (C-SSRS) ScorePre-intervention, Post-intervention (Up to six weeks)

    Columbia-Suicide Severity Rating Scale (C-SSRS; Posner et al., 2011) serves as the outcome measure, which assesses the constructs of suicidal behavior (i.e., actual, aborted, or interrupted attempts), severity, and lethality. Although suicidal behavior is the primary outcome of interest, suicidal ideation (passive, active, intensity) will also be assessed by the C-SSRS. The C-SSRS has four constructs relevant to recent suicidal ideation (SI): 1) severity (1=wish to be dead, 2=nonspecific active suicidal thoughts, 3=suicidal thoughts with methods, 4=suicidal intent, and 5=suicidal intent with plan); 2) intensity (sum across six items each rated 0 to 5: most severe ideation, frequency, duration, controllability, deterrents, and reason); 3) behavior; and 4) lethality.