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Observational Study of Rod and Cone Function in Retinal Disease

This observational study aims to understand how rod and cone photoreceptors (light-sensing cells in your eye) work in both healthy individuals and those with retinal diseases like Retinitis Pigmentosa and Stargardt's Disease. Researchers want to see if measuring how well a person sees in the dark can help determine how severe their retinal disease is, detect the disease early, and track its changes over time. The study will establish normal ranges for how quickly your eyes adapt to darkness and how sensitive your retina is to light. You can participate if you are at least five years old and have a retinal disease or have good vision (20/20 or better in at least one eye). The study is currently ongoing.

Study design
This is an observational study involving up to 500 participants, including 250 healthy volunteers and 250 individuals with retinal disease.
What's involved
You would undergo medical and eye history screenings, eye exams, and various tests to measure your rod and cone function, potentially over up to 10 visits within 5 years.
Compensation
Not stated in the trial record.
Follow-up
Your participation could involve follow-up visits for up to 5 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT02617966

Rod and Cone Mediated Function in Retinal Disease

Recruiting
Not specifiedAges 5+Observational
National Eye Institute (NEI)
~500 participants
Updated 2026-08-28 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
The primary outcomes for this study are to establish normal ranges for the kinetics of dark adaptation and dark-adapted retinal sensitivity for the fundus guided and non-guided perimeters and for RF hyperacuity on the Display++.
Measured over ongoing, up to 10 visits in 5 years

Conditions

Retinal Degeneration
Retinitis Pigmentosa
Stargardt's Disease

Explore related trials

Retinal DegenerationRetinitis PigmentosaStargardt Disease

Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • Brett G Jeffrey, Ph.D. · PRINCIPAL_INVESTIGATOR · National Eye Institute (NEI)

Who to contact

Daniel W Claus, R.N.
[email protected]
(301) 451-1621
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Participant must be five years of age or older.
Participant (or legal guardian) must understand and sign the protocol s informed consent document.
Participant must be able to cooperate with the testing required for this study.
Participant must have retinal disease, defined as evidence of loss of retinal dysfunction and/or degeneration as established by standard clinical methods including perimetry, ERG and imaging.
Participant must have a measurable visual acuity.
Participant must have visual acuity of 20/20 or better, with or without correction (e.g., glasses or contact lens) in at least one eye.

Exclusion

Participant with changes in pre-retinal media sufficient to obscure a view of the retina.

What this trial measures

  • The primary outcomes for this study are to establish normal ranges for the kinetics of dark adaptation and dark-adapted retinal sensitivity for the fundus guided and non-guided perimeters and for RF hyperacuity on the Display++.ongoing, up to 10 visits in 5 years

    The primary outcomes for this study are to establish normal ranges for the kinetics of dark adaptation and dark-adapted retinal sensitivity for the fundus guided and non-guided perimeters and for RF hyperacuity on the Display++.