The WISDOM Study is looking for women aged 30 to 74 in the United States to explore better ways to screen for breast cancer. Currently, many women receive annual mammograms (X-rays of the breast) starting at age 40, but this approach can lead to false alarms and unnecessary procedures. This study aims to see if a personalized screening plan, based on your individual risk factors, is more effective. You would either receive screening advice based on a comprehensive risk assessment (including a health questionnaire and a saliva sample for genetic testing, looking for genes like BRCA that influence breast cancer risk) or advice based on a basic risk assessment. Researchers will compare these approaches to see if they can reduce late-stage cancers and the number of biopsies (tissue removal for examination) needed over at least five years.

Study design

This interventional study plans to enroll 100,000 participants. It compares two different approaches to breast cancer screening advice.

What's involved

You would complete a health questionnaire and may provide a saliva sample for genetic testing. You would then receive a screening schedule recommendation.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed for at least 5 years to measure late-stage cancer rates and biopsy rates.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.