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Uterine Transplant for Absolute Uterine Infertility

This study is exploring uterine transplant as a way for women with Absolute Uterine Factor Infertility (AUFI) to carry a pregnancy. AUFI means you cannot carry a pregnancy due to problems with your uterus, such as being born without one or having it removed. The study will involve a uterine transplant procedure using a uterus from a living donor. Before the transplant, you would undergo IVF (in vitro fertilization) to create and freeze at least six embryos. About one year after the transplant, these embryos would be transferred to achieve pregnancy, with delivery by C-section. The main goal is to see how many successful live births happen after the transplant and embryo transfer. This study is currently recruiting a small number of participants, aiming for 3 women aged 18-40 who meet specific health and weight criteria.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 3 participants.
What's involved
Participants will undergo IVF, a uterine transplant, embryo transfer, and delivery by C-section. After the uterus is removed, five years of follow-up is planned.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for five years after the uterus is removed.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT02741102

Uterine Transplant in Absolute Uterine Infertility (AUIF)

Recruiting
PHASE2Ages 18–40InterventionalTreatment
Brigham and Women's Hospital
~3 participants
Updated 2026-07-06 on ClinicalTrials.gov
What's tested:Uterine Transplant

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of successful live births following uterus transplant/embryo transfer
Measured over 2 years after uterine transplant

Conditions

Female Infertility

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NCT02741102

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Brigham and Women's Hospital

    Boston, Massachusettsno site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Stefan G Tullius, M.D. · PRINCIPAL_INVESTIGATOR · Brigham and Womens Hospital

Who to contact

Stefan G Tullius, M.D.
[email protected]
617-732-6866
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Age 18-40
Clinical evidence of AUFI (Absolute Uterine Factor Infertility)
Able to produce at least 6 normal embryos by IVF for future use
Reasonable weight with BMI (Body Mass Index) less than 30.
Normal kidney function
Able to undergo transplant and be compliant with treatment
Has stable partner and social supports
Partner willing to undergo psychological evaluation and receive immunizations as recommended
Stable home environment to support a child
Age over 40 up to age 60
Has completed having a family
Previous pregnancies were carried to term (no miscarriages)
Able to take a birth control pill containing estrogen
Weight reasonable with BMI (Body Mass Index) of 30 or less
Good social supports

Exclusion

Active smoking, alcohol use or use of illicit drugs
Inability to comply with required treatment (taking pills, having biopsies, frequent appointments )
Having a condition that would make pregnancy or taking anti rejection medicines too risky.
Active infection: Human Immunodeficiency Virus (HIV) , Tuberculosis, Hepatitis B, Hepatitis C
History of extensive abdominal or pelvic surgery
History of abnormal Papanicolaou test (PAP smear) or genital warts
History of pelvic inflammatory disease
Active smoking, alcohol use or use of illicit drugs
Psychiatric illness
Cervical or endometrial polyps (growths) or tumors in the uterus muscle
History of more than 1 Caesarean section
History of abnormal PAP smear or genital warts
Internal scarring from extensive abdominal or pelvic surgery
Hypertension, Coronary artery disease, Chronic Obstructive Lung disease (emphysema) and Diabetes
Active cancer or incompletely treated cancer
Active infection including Human Immunodeficiency Disease (HIV) , Tuberculosis, Hepatitis B or Hepatitis C
Significant history of either blood clots or bleeding tendencies
Evidence of coercion or exchange of money or goods for donating the organ

What this trial measures

  • Number of successful live births following uterus transplant/embryo transfer2 years after uterine transplant

    Full term live birth by caesarian section after uterus transplant and IVF