Hereditary Risk Factors for Thyroid Cancer Study

This study is looking into why some thyroid cancers (cancers of a gland in your neck that makes hormones) and thyroid nodules (lumps in the thyroid) run in families. Researchers want to understand the genes and other factors that might increase your risk. If you have a history of thyroid cancer or nodules as a child, or if your family has a strong history of thyroid cancer, you might be able to join. The study involves collecting your family and medical history, and a blood or saliva sample for genetic testing. The main goals are to count how many participants have childhood or suspected family-related thyroid issues and to find specific gene changes linked to thyroid cancer risk. The study is currently unclear on its recruitment status.

Study design
This is an interventional study planning to enroll 250 participants. It is designed to investigate hereditary risk factors for thyroid cancer.
What's involved
You would provide family and medical history information, along with a blood or saliva sample for genetic studies. If needed, you might be referred to a genetic counselor.
Compensation
Not stated in the trial record.
Follow-up
The primary outcomes of the study will be measured at 2 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT02747888

Hereditary Risk Factors for Thyroid Cancer

Recruiting
NAAll AgesInterventionalScreening
Dana-Farber Cancer Institute
~250 participants
Updated 2026-06-11 on ClinicalTrials.gov
What's tested:•Referral to Genetic Counselor, if indicated

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of participants who have childhood or suspected familial thyroid nodules/cancer
Measured over 2 years
+2 more outcomes measured
Thyroid Cancer
1 sites across 1 states
Massachusetts1
  • Junne Kamihara, MD, PhD · PRINCIPAL_INVESTIGATOR · Dana-Farber Cancer Institute

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Individual pediatric patient with current or previous known or suspected thyroid cancer or nodule(s).
Individual adult patient with current or previous known or suspected thyroid cancer or nodule(s) if they come from a family with a high suspicion of hereditary cancer (as below).
Individuals from families with a high suspicion of hereditary thyroid cancer:
Families with a current or previous diagnosis of a thyroid cancer/nodule occurring in childhood (\<18 years old).
Families with a high suspicion of hereditary thyroid cancer/nodules other than above to include:
Families with thyroid cancer in multiple individuals
Families with thyroid cancer and a known genetic syndrome
Families with thyroid cancer and a suspected genetic syndrome (e.g. multiple childhood cancers in the family, multiple primary cancers, multiple endocrinopathies, etc.)

Exclusion

Individuals who are unable to give informed consent.
Individuals who are unable to complete study materials.
  • Number of participants who have childhood or suspected familial thyroid nodules/cancer2 years
  • Number of germline mutations identified associated with thyroid cancer predisposition2 years
  • Prevalence of suspected familial thyroid cancer among those with childhood thyroid nodules/cancer2 years