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Electrocorticography for Brain Tumor Surgery

This study is looking at how well electrocorticography (ECoG) works to map important brain areas during surgery for brain tumors. ECoG uses special grids placed on the brain to help doctors identify areas responsible for movement and speech. The goal is to see if using these grids, which are larger or more detailed than standard ones, can help doctors better understand which parts of your brain are active during specific tasks. This could help them remove as much of the tumor as possible while protecting important brain functions. You may be able to join if you are at least 18 years old, have a new or recurring brain tumor, and are having surgery at the University of Texas M. D. Anderson Cancer Center.

Study design
This is an interventional study planning to enroll 75 participants. It compares ECoG with current mapping methods like fMRI and TMS, and the standard direct electrical stimulation.
What's involved
During surgery, you will undergo electrocorticography using a special grid and direct electrocortical stimulation. You will have follow-up visits within 24 hours after surgery and at 1, 3, and 6 months.
Compensation
Not stated in the trial record.
Follow-up
Participants are followed for up to 6 months after surgery.

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NCT02754544

Electrocorticography in Mapping Functional Brain Areas During Surgery in Patients With Brain Tumors

Recruiting
NAAges 18+InterventionalDiagnostic
M.D. Anderson Cancer Center
~75 participants
Updated 2026-05-20 on ClinicalTrials.gov
What's tested:Direct Electrocortical StimulationElectrocorticography

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Electrocorticogram (ECoG)
Measured over Up to 6 months (± 4 weeks)

Conditions

Brain Neoplasm
Metastatic Malignant Neoplasm in the Brain
Recurrent Brain Neoplasm

Explore related trials

Brain Neoplasm

Where it's being run

1 sites across 1 states
Texas1

Study leadership

  • Sujit S Prabhu · PRINCIPAL_INVESTIGATOR · M.D. Anderson Cancer Center

Who to contact

Sujit Prabhu, MD
[email protected]
713-792-2400
Email the study team

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Eligibility criteria

Inclusion

Patients undergoing a tumor resection at the University of Texas M. D. Anderson Cancer Center for a newly diagnosed as well as recurrent primary or metastatic brain tumor located in or adjacent to motor and/or speech brain areas
Patients \>= 18 years of age
Signed informed consent

Exclusion

Patients with significant neurological motor deficits of the upper extremities, and/or speech deficits, which would preclude them from performing the while awake intra-operative tasks at the discretion of the principal investigator (PI)
Patients who have impaired vision and/or hearing and whose performance could affect the study will be excluded at the discretion of the PI

What this trial measures

  • Electrocorticogram (ECoG)Up to 6 months (± 4 weeks)

    Will be assessed by cortical electrical activity based on individual hand muscle function. ECoG will be compared to direct electrical stimulation (DES), navigated transcranial magnetic stimulation (nTMS), and functional magnetic resonance imaging (fMRI). The data obtained using ECoG will be correlated with the fMRI and TMS data acquired preoperatively and intraoperative DES. The categorical variables would be preoperative Karnofsky performance status and functional status, tumor location, fMRI, TMS, ECoG, and DES data points. Other variables involved in the analysis would be extent of resection and neurological and language/speech outcome. The Chi-square or Fisher's exact tests will be used to explore associations between categorical variables. Additional analysis may be performed.