Evaluation of Children With Endocrine and Metabolic-Related Conditions

This observational study aims to understand more about endocrine (hormone-related) and metabolic (how your body uses energy) conditions in children. Researchers want to identify the genes involved in these disorders, which could lead to better ways to diagnose and treat them. This study offers an opportunity for children with known or suspected endocrine or metabolic disorders to be evaluated at the National Institutes of Health (NIH). Family members may also participate, especially for genetic testing, to help understand how these conditions are inherited. The study will track the natural progression of these conditions in a diverse group of children.

Study design: This is an observational study with a planned enrollment of 15,000 participants. It is designed to allow for comprehensive evaluations of pediatric endocrine diseases and conditions.
What's involved: Participants will be screened through a review of their medical records. They may undergo standard laboratory or radiological studies, and in some cases, receive medical or surgical treatment at the NIH Clinical Center.
Compensation: Not stated in the trial record.
Follow-up: The primary endpoints are measured at Baseline, focusing on providing evaluation options and recruiting diverse subjects. Long-term follow-up beyond this is not specified.

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Evaluation of Children With Endocrine and Metabolic-Related Conditions

Recruiting

Not specifiedAges 3+Observational

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

~15,000 participants

Updated 2026-08-13 on ClinicalTrials.gov

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Provide an option for patients with unusual or challenging endocrine or metabolic conditions, who may or may not be eligible for an existing research protocol, to be evaluated at NIH.

Measured over Baseline

+1 more outcome measured

Conditions

Adrenal Insufficiency

Growth Disorder

Endocrine Diseases

Metabolic Disease

Bone Diseases, Metabolic

Where it's being run

1 sites across 1 states

Maryland1

Study leadership

Catherine M Gordon, M.D. · PRINCIPAL_INVESTIGATOR · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Who to contact

Harinder D Raipuria, C.R.N.P.

[email protected]

(301) 254-2982

Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Participants with known or suspected endocrine disorder age 3 months-18 years are eligible for this protocol.

Relatives ages 3 months-100 years may be enrolled if clinically indicated for the diagnosis of a proband.

Exclusion

Lack of suspected endocrine disorders.

Any medical, physical, psychiatric, or social conditions, which, in the opinion of the investigators, would make participation in this protocol not in the best interest of the patient, will exclude participation. Patients who are critically ill, unstable, or with severe organ failure that may affect/limit the endocrine evaluation and place unsustainable demands on Clinical Center or NICHD resources will be excluded.

What this trial measures

Provide an option for patients with unusual or challenging endocrine or metabolic conditions, who may or may not be eligible for an existing research protocol, to be evaluated at NIH.Baseline
Provide an option for patients with unusual or challenging endocrine or metabolic conditions, who may or may not be eligible for an existing research protocol, to be evaluated at NIH.
Recruit a diverse population of pediatric subjects with a known or suspected endocrine or metabolic disorder in order to provide NICHD investigators and trainees with hands-on experience related to the diagnosis, management, treatment, and follo...Baseline
Recruit a diverse population of pediatric subjects with a known or suspected endocrine or metabolic disorder in order to provide NICHD investigators and trainees with hands-on experience related to the diagnosis, management, treatment, and follow-up of p

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