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Understanding Childhood Melanocytic Lesions

This study aims to learn more about childhood melanocytic lesions, which include different types of melanoma and other skin growths. Researchers will collect samples of these lesions from children and teenagers up to 18 years old. They will look at the DNA and RNA in these samples to find genetic changes that might be linked to how these lesions develop or how they respond to treatment. They will also compare these changes to those found in blood cells. The study will also gather basic information about the treatments participants receive, such as chemotherapy or surgery, and how well the lesions respond. This is an observational study, meaning no new treatments are given; researchers are simply studying existing information and tissue samples to better understand these conditions.

Study design
This is an observational study planning to enroll 500 participants. It is not a treatment study, but rather focuses on collecting and analyzing information.
What's involved
If you join, leftover tissue from your regular medical care will be studied. A small amount of blood (1-3 tablespoons) will also be collected.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT02775643

Molecular Analysis of Childhood and Adolescent Melanocytic Lesions

Recruiting
Not specifiedUp to 18Observational
St. Jude Children's Research Hospital
~500 participants
Updated 2025-11-10 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Genomic profile
Measured over At participant enrollment

Conditions

Melanoma

Explore related trials

Congenital melanosisCutaneous Spitz MelanomaMelanocytic lesions with indeterminate biological behaviorMelanomaMelanoma Arising in Giant NeviPigment synthesizing melanomas

Where it's being run

1 sites across 1 states
Tennessee1

Study leadership

  • Alberto Pappo, MD · PRINCIPAL_INVESTIGATOR · St. Jude Children's Research Hospital

Who to contact

Alberto Pappo, MD
[email protected]
866-278-5835
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Participant has a suspected or confirmed diagnosis of a melanocytic lesion, including:
Conventional or "adult-type" melanoma
Spitzoid melanoma/atypical Spitz tumor
Congenital melanoma
Melanoma arising in a giant congenital nevus
Melanocytic lesions with indeterminate biological behavior (e.g., pigment synthesizing melanomas)
Participant was \<19 years of age at the time of diagnosis.
Tissue is available for biologic studies.
Participant has been enrolled on the TBANK protocol at SJCRH, or will be enrolled before any research tests are performed on their biological materials.

Exclusion

Ocular melanoma
Inability or unwillingness of research participant or legal guardian to consent.
Histologic diagnosis other than melanocytic lesion described in 3.1.1.

What this trial measures

  • Genomic profileAt participant enrollment

    Pathology/molecular samples may be available in pathology banking system or may be obtained at the same time as specimens are taken from individual consenting participants (time varies according to specific therapeutic protocol). A comprehensive molecular analysis of tumor samples either from paraffin embedded and/or frozen tissue from patients will be performed. Summary statistics will be calculated for the pathology/molecular data.