Understanding Gender Differences in THC Effects

This study is looking at how Delta-9-Tetrahydrocannabinol (THC), the main active ingredient in cannabis, affects men and women differently. You might be able to join if you are a healthy adult between 18 and 55 years old, have used cannabis before, and are in good physical and mental health. However, you cannot join if you've never used cannabis, are experiencing major stress, or, for women, if you are taking estrogen supplements or birth control pills. Researchers will give participants either active THC or a placebo (a control substance with no THC). They will measure how "high" participants feel and test verbal learning to see the effects. The study aims to understand these differences, but the current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 100 participants. It compares the effects of active THC to a placebo.
What's involved
You would receive either active THC or a placebo. Researchers will measure your "high" at baseline, 10, 80, and 200 minutes after the THC infusion begins, and test your verbal learning 25 minutes after the infusion starts.
Compensation
Not stated in the trial record.
Follow-up
Your "high" will be measured up to 200 minutes after the THC infusion begins, and verbal learning will be tested 25 minutes after the infusion begins.

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NCT02781519

Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans

Recruiting
PHASE1Ages 18–55InterventionalBasic science
Yale University
~100 participants
Updated 2025-06-10 on ClinicalTrials.gov
What's tested:THCPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Rewarding Effects measured by Visual Analog Scale (VAS)
Measured over changes in "high" assessed over the following timepoints: baseline, +10, +80, and +200 minutes after THC infusion begins
+1 more outcome measured
Cannabis
1 sites across 1 states
Connecticut1

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Eligibility criteria

Inclusion

at least one lifetime exposure to cannabis
good physical and mental health

Exclusion

cannabis naive individuals
major current or recent stressors
taking estrogen supplements or oral contraceptive pills (for women)
  • Rewarding Effects measured by Visual Analog Scale (VAS)changes in "high" assessed over the following timepoints: baseline, +10, +80, and +200 minutes after THC infusion begins

    subjective measure of THC induced "high"

  • Verbal Learning: measured by Rey Auditory Verbal Learning Test (AVLT)25 minutes after THC infusion begins

    measured as delay recall on the AVLT