Bariatric Surgery and Glucose Metabolism Study

This study is looking at how gastric bypass and sleeve gastrectomy surgeries affect how your body handles sugar (glucose metabolism). Researchers want to understand the roles of hormones and nerves after you eat. They are testing two drugs: Exendin-(9-39) and Atropine, to see how they impact glucose and insulin levels. You might be able to join if you are between 18 and 65 years old and have had bariatric surgery with low blood sugar (hypoglycemia), or if you've had bariatric surgery without symptoms, or if you are a healthy person who hasn't had surgery and doesn't have diabetes. The main goal is to measure insulin levels after you eat. The study aims to enroll 200 participants, but its current status is unclear.

Study design
This is an interventional study, meaning participants will receive specific treatments. It plans to enroll 200 participants.
What's involved
Each study in the protocol is conducted for up to seven hours, with data collected at specific intervals. You must be able to physically come to the Cedars-Sinai Medical Center.
Compensation
Not stated in the trial record.
Follow-up
Insulin levels are measured after nutrient ingestion, with data collected at intervals specific to the individual study procedure, for up to seven hours.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT02823665

The Effects of Bariatric Surgeries on Glucose Metabolism

Recruiting
EARLY_PHASE1Ages 18–65Interventional
The University of Texas Health Science Center at San Antonio
~200 participants
Updated 2025-09-09 on ClinicalTrials.gov
What's tested:Exendin-(9-39)Atropine

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Insulin levels measured after nutrient ingestion
Measured over Each study in the protocol is conducted up to seven hours with data collected at intervals specific to the individual study procedure.
Post Bariatric Surgery
Gastric Bypass
Sleeve Gastrectomy
Hypoglycemia After Gastric Bypass
2 sites across 1 states
Texas2
  • Marzieh Salehi, MD, MS · PRINCIPAL_INVESTIGATOR · The University of Texas Health Science Center at San Antonio

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Hypoglycemic RYGB patients with documented blood glucose level \<50 mg/dl
Asymptomatic individuals with bariatric surgery
Healthy non-surgical patients with no personal history of diabetes
Subjects must physically be able to come to our clinical research center Cedars-Sinai Medical Center

Exclusion

Active heart, lung, liver, gastrointestinal or kidney disease; unable to give informed consent; pregnancy; uncontrolled high blood pressure or high cholesterol; significant anemia (hemoglobin \<11g/dL); prisoners or institutionalized individuals; type 2 diabetes mellitis; development of any serious medical or psychiatric illness during recruitment or studies;
RYGB patients will be disqualified if they have gastric outlet obstruction or severe diarrhea.
Healthy non-surgical patients with personal history of diabetes
History of glaucoma
Uncontrolled hypertension (any subjects with BP\>140/90 and history of dyslipidemia
Taking any medication that might interact with atropine and cannot be stopped will be excluded from the study)
Myasthenia gravis
Brain pathology
Enlarged prostate in men
  • Insulin levels measured after nutrient ingestionEach study in the protocol is conducted up to seven hours with data collected at intervals specific to the individual study procedure.