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The Will Erwin Headache Research Center - Cluster Headache Study

This study is gathering information from people who have cluster headache and similar conditions like paroxysmal hemicrania and SUNCT. It's an observational study, meaning researchers will collect detailed information about your condition, medical history, and other health factors over an average of five years. They want to understand more about these headaches and how they affect people, including sleep patterns, anxiety, and overall headache impact. This study is open to adults aged 18 and older who have been diagnosed with one of these specific headache types. The goal is to create a national registry to better understand these conditions and help match patients with future treatment studies.

Study design
This is an observational study aiming to enroll 1500 participants. It is not a treatment study, but rather collects information about your condition.
What's involved
Detailed evaluations and classification will be completed for each enrolled subject, including genomic and epigenomic studies, past medical history, imaging reports, and specific physical exam results. This will occur over an average of five years.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed through study completion, an average of 5 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT02910323

The Will Erwin Headache Research Center - Cluster Headache Study

Recruiting
Not specifiedAges 18+Observational
The University of Texas Health Science Center, Houston
~1,500 participants
Updated 2026-02-18 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
HIT-6 scale
Measured over Through study completion, an average of 5 years
+2 more outcomes measured

Conditions

Cluster Headache
Cluster Headaches and Other Trigeminal Autonomic Cephalgias
Paroxysmal Hemicrania
SUNCT
Hemicrania Continua
Trigeminal Neuralgia

Explore related trials

Cluster HeadacheHemicrania ContinuaParoxysmal hemicraniaSingle Umbilical ArterySUNCTTrigeminal Autonomic CephalalgiaTrigeminal neuralgia

NCT02910323

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • The University of Texas Health Science Center at Houston

    Houston, Texasstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Mark Burish, MD, PhD · PRINCIPAL_INVESTIGATOR · The University of Texas Health Science Center, Houston

Who to contact

Rebecca Martinez, RN
[email protected]
713-486-7771
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Want this trial checked against your situation?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Diagnosis of a trigeminal autonomic cephalalgia according to the International Headache Classification including episodic cluster headache, chronic cluster headache, episodic paroxysmal hemicrania, chronic paroxysmal hemicrania, episodic short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT), chronic SUNCT, episodic short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA), chronic SUNA, and hemicrania continua. OR Diagnosis of a trigeminal neuralgia according to the International Headache Classification, including classical trigeminal neuralgia and symptomatic trigeminal neuralgia.
Able to provide HIPAA authorization to share prior medical records/imaging.

Exclusion

Life expectancy less than 1 year, co-existing disease or other characteristic that precludes appropriate diagnosis of a trigeminal autonomic cephalalgia or trigeminal neuralgia.
Active drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements
Inability or unwillingness of subject or legal guardian/representative to give informed consent.

What this trial measures

  • HIT-6 scaleThrough study completion, an average of 5 years
  • Morningness-eveningness scaleThrough study completion, an average of 5 years
  • GAD-7 scaleThrough study completion, an average of 5 years